| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V104745 | 21H7 | 217317-45-8 | 21H7 is a selective inhibitor of the Wnt/b-catenin pathway. |
|
V102465 | 3289-8625 | 294891-81-9 | 3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM), which inhibits Wnt signaling. |
|
V84636 | 4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) | 3374-77-4 | |
|
V80838 | 8BTC | 8BTC (compound 4w) is a potent covalent Notum inhibitor (antagonist) with IC50 of 2.5 nM. | |
|
V69164 | ABC99 | 2331255-53-7 | BC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). |
|
V69166 | Box5 | 1206604-29-6 | Box5 is a potent Wnt5a antagonist. |
|
V77189 | Box5 TFA | Box5 TFA is a potent Wnt5a antagonist. | |
|
V88134 | C1s Enzyme | C1s Enzyme is a subunit of the complement C1 complex and can activate complement as a serine protease. | |
|
V69165 | Carboxylesterase-IN-3 | 2764748-92-5 | Carboxylesterase-IN-3 (compound 4y) is a potent Carboxylesterase Notum inhibitor (antagonist) with IC50 less than or equal to 10 nM. |
|
V69169 | Cardionogen 1 (CDNG1/vuc230) | 577696-37-8 | Cardionogen 1 (CDNG1/vuc230) is a Wnt signaling pathway inhibitor that can slow down Myc-induced liver tumorigenesis. |
|
V98449 | CCT070535 | 485319-41-3 | CCT070535 blocks TCF-dependent transcription at the TCF level, with GI50 values of 17.6 μM, 11.1 μM, 11.8 μM, and 13.4 μM in HT29 (APC mutation), HCT116 (oncogenic β-catenin), SW480 (APC mutation), and SNU475 (Axin mutation) cells, respectively. |
|
V106084 | Dalbinol | 41993-79-7 | Dalbinol is a rotenone compound that can inhibit the Wnt/β-catenin signaling pathway, promote the degradation of β-catenin, effectively inhibit tumor cell proliferation, induce cell apoptosis, and has anti-tumor activity. |
|
V103516 | DHC-156 | DHC-156 is a selective small molecule Brachyury downregulator. | |
|
V105088 | Fluc-IN-1 | 2940242-10-2 | Fluc-IN-1 (Compound 3) is an inhibitor of firefly luciferase with IC50 of 25 nM. |
|
V77001 | Foxy-5 TFA | Foxy-5 TFA is a WNT5A agonist, a mimetic peptide of WNT5A, and a non-classical member of the Wnt family. | |
|
V86268 | Fz7-21S | 2247635-24-9 | |
|
V85009 | FZD7 antagonist 1 | 2416664-25-8 | |
|
V69163 | Ipafricept (OMP-54F28; FZD8-Fc) | 1391727-24-4 | Ipafricept (OMP-54F28; FZD8-Fc) is a first-in-class recombinant fusion protein consisting of the extracellular portion of the human Frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands. |
|
V69168 | IWP-2-V2 | 877618-79-6 | IWP-2-V2 is an IWP-2 analog that retains activity on the Wnt/β-catenin pathway. |
|
V106369 | KP-6 | 2102414-23-1 | KP-6 is a peptide that is a Wnt/β-catenin signaling inhibitor. |
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