White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75024 | IL-17 modulator 5 | 2724206-27-1 | IL-17 modulator 5 (compound 26) is an inhibitor (blocker/antagonist) of IL-17 with IC50 of 1 nM. |
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V75043 | IL-17 modulator 8 | 1608097-49-9 | IL-17 modulator 8 (compound 286) is an orally bioactive modulator of IL-17. |
|
V75014 | IL-17 modulator 9 | 1449211-26-0 | IL-17 modulator 9 (compound 453) is an orally bioactive modulator of IL-17. |
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V96666 | IL-17-IN-1 | IL-17-IN-1 (26) is an orally active IL-17 inhibitor with IC50 values of 0.013 μM and 0.004 μM for IL-17A and IL-6 release, respectively. | |
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V93559 | IL-17-IN-2 | 3058278-46-6 | IL-17-IN-2 (Example 51) is a potent inhibitor of IL-17 with IC50 of less than 0.4 μM in HTRF and NHK assays. |
|
V74931 | IL-17A antagonist 1 | 2205034-18-8 | IL-17A antagonist 1 (compound 1) is an IL-17A antagonist (inhibitor) with a Kd of 0.66 μM and IC50 of 1.14 μM. |
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V74981 | IL-17A antagonist 3 | 2230780-65-9 | IL-17A antagonist 3 is an IL-17A antagonist, compound 3. |
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V74929 | IL-17A inhibitor 1 | 2452464-73-0 | IL-17A inhibitor 1 (example 24) is an inhibitor (blocker/antagonist) of IL-17A, with IC50s of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells, respectively. |
|
V75012 | IL-17A inhibitor 2 | 2452464-77-4 | IL-17A inhibitor 2 is an IL-17A inhibitor studied in psoriasis, rheumatoid arthritis, and multiple sclerosis. |
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V93562 | IL-17A inhibitor 3 | 2632336-05-9 | IL-17A inhibitor 3 (Example 602) is a potent IL-17A inhibitor. |
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V93695 | IL-17A inhibitor 4 | 2735650-99-2 | IL-17A inhibitor 4 (Example 449) is a potent IL-17A inhibitor. |
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V74944 | IL-17A modulator-1 | 2748749-29-1 | IL-17A modulator-1 is an IL-17A modulator from patent WO2021239743+A1, example 9. |
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V74964 | IL-17A modulator-2 | 2748749-47-3 | IL-17A modulator-2 is an IL-17A modulator from patent WO2021239743+A1, example 27. |
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V75044 | IL-17A modulator-3 | 2467732-95-0 | IL-17A modulator-3 (compound 253) is a modulator of IL-17A. |
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V75026 | IL-1β-IN-1 | 2780364-50-1 | IL-1β-IN-1 is a cannabidiol analogue and a potent inhibitor of IL-1β. |
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V75035 | IL-1β-IN-2 | 2242896-76-8 | IL-1β-IN-2 is a cannabidiol analogue and a potent inhibitor of IL-1β. |
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V97195 | IL-23R inhibitor peptide-1 | 2894052-23-2 | IL-23R inhibitory peptide-1 (comp 475) is an inhibitor of interleukin-23 receptor with IC50 of 0.0069 μM. |
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V84583 | IL-33 probe-1 | ||
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V74938 | IL-4-inhibitor-1 | 1332184-63-0 | IL-4-inhibitor-1 (compound 52) is an inhibitor (blocker/antagonist) of IL-4 with EC50 of 1.81 µM. |
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V80356 | IL-6 aptamer sodium | IL-6 aptamer sodium is a nucleic acid aptamer that specifically targets IL-6 and can be used for the specific detection of IL-6. |
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