A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76345 | Wnt/β-catenin agonist 3 hydrochloride | Wnt/β-catenin agonist 3 HCl is an agonist of the Wnt/β-catenin signaling pathway. | |
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V81762 | xStAx-VHLL | xStAx-VHLL is a PROTAC β-catenin degrader that displays strong Wnt signaling inhibition and maintains β-catenin degradation in cancer cells and intestinal organoids of wild-type and APC–/– mice. | |
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V69185 | ZW4864 | 2632259-93-7 | ZW4864 is an orally bioactive and selective inhibitor of β catenin/B-Cell lymphoma 9 protein-protein interaction (β catenin/BCL9 PPI). |
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V67504 | ZW4864 free base | 2632259-92-6 | ZW4864 (free base) is an orally bioactive and selective inhibitor of β catenin/ B-Cell lymphoma 9 protein-protein interaction (β catenin/BCL9 PPI). |
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V67508 | β-Catenin modulator-2 | 1015858-71-5 | β-Catenin modulator-2 (compound IIa-130) is an oxazole and thiazole compound that is a potent and specific β-Catenin modulator. |
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V67516 | β-Catenin modulator-4 | 901751-85-7 | β-Catenin modulator-4 (compound IIa-92) is an oxazole and thiazole compound that is a potent and specific β-Catenin modulator. |
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V67515 | β-Catenin modulator-5 | 902168-07-4 | β-Catenin modulator-5 (compound IIa-84) is an oxazole and thiazole compound that is a potent and specific β-Catenin modulator. |
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V67502 | β-catenin-IN-2 | 1458664-10-2 | β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, disclosed in patent US20150374662A1. |
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V51022 | β-catenin-IN-37 | 1783856-40-5 | β-catenin-IN-37 is a selective amplification of β-catenin/T-cell factor protein interaction (β-catenin/Tcf PPI). |
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V69184 | β-catenin-IN-6 | 1039731-99-1 | β-catenin-IN-6 is a β-catenin inhibitor that targets the canonical wingless-related integration site signaling pathway. |
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V81812 | β-catenin-IN-7 | β-catenin-IN-7 (Compound 9) is a β-catenin inhibitor. |
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