Small Interfering RNA (siRNA) is a small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The sense strand is broken down as the short dsRNA unwinds. With various protein components, the antisense strand forms the RNA-induced silencing complex (RISC). The target gene's mRNA is specifically complementary to the antisense strand that RISC retains. The target gene's mRNA can be cut and degraded by the nuclease activity of RISC, which can also stop the target gene from being expressed. Inhibition of mRNA translation is the result of incomplete complementarity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V81290 | Revusiran sodium (ALN-TTRSC sodium) | Revusiran sodium is a first-generation short interfering RNA targeting transthyretin (TTR) mRNA. | |
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V76512 | SiRNA Negative Control | SiRNA negative control (NC) is a 21-nucleotide siRNA that can be used as a negative control (NC). | |
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V51393 | SS(no Galnac)-Inclisiran | SS(no Galnac)-Inclisiran is a sense strand of Inclisiran without the asialoglycoprotein receptor (GalNAc). | |
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V70115 | Tivanisiran (SYL1001) | 1848224-71-4 | Tivanisiran (SYL1001) is an siRNA used in dry eye disease study. |
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V81770 | Zerlasiran sodium | Zerlasiran sodium is an inhibitor (blocker/antagonist) of apolipoprotein A (ApoA) synthesis. |
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