The mTOR gene in humans produces the protein known as mTOR (mammalian target of rapamycin). A serine/threonine protein kinase called mTOR controls transcription, protein synthesis, cell motility, growth, and proliferation in living things. The phosphatidylinositol 3-kinase-related kinase protein family includes mTOR. Growth factors and amino acids are just two examples of the input from upstream pathways that mTOR integrates.Additionally, mTOR detects cellular energy, oxygen, and nutrient levels. In human diseases like diabetes, obesity, depression, and some cancers, the mTOR pathway is dysregulated. By collaborating with its intracellular receptor FKBP12, rapamycin inhibits mTOR. The mTOR FKBP12-Rapamycin Binding (FRB) domain is directly contacted by the FKBP12-rapamycin complex, which inhibits mTOR activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V2177 | (+)-Usniacin | 7562-61-0 | Usniacin, [(+)-Usnic acid] is a natually occuring compound isolated from lichens, which binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. |
|
V102460 | (2S,6S)-Hydroxynorketamine hydrochloride | 1430202-70-2 | (2S,6S)-Hydroxynorketamine hydrochloride is a neuroleptic active molecule with potential antidepressant and analgesic effects. |
|
V70240 | (32-Carbonyl)-RMC-5552 | 2382768-55-8 | (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. |
|
V122024 | (Rac)-LRK-4189 | 3063345-48-9 | (Rac)-LRK-4189 is the racemic form of LRK-4189. |
|
V122027 | (rac)-Monepantel | 851976-50-6 | (rac)-Monepantel is the racemic form of Monetpantel. |
|
V122230 | (S)-WSD0628 | 2765449-10-1 | (S)-WSD0628 is the S-isomer of WSD0628. |
|
V123469 | 1-Acetyl-DHAP | 2267338-53-2 | 1-Acetyl-DHAP is a substrate of phosphotriesterase homolog (PHP) and can be hydrolyzed by PHP. Its catalytic rate constant kcat/km is 100 M⁻¹s⁻¹. |
|
V70255 | 10-Hydroxy-2-decenoic acid (10-HDA) | 765-01-5 | 10-Hydroxy-2-decenoic acid (10-HDA) is the main lipid component of royal jelly produced by bees. |
|
V104896 | 2DII | 2DII is a potent and selective mTORC2 inhibitor. | |
|
V9496 | 3BDO | 890405-51-3 | 3BDO is a butyrolactone analog which acts as amTOR activator, ittargets FKBP1A and activate the mTOR signaling pathway. |
|
V97457 | 4-FPBUA | 2089636-93-9 | 4-FPBUA is a semisynthetic analog of lichenic acid that enhances cell-based blood-brain barrier (BBB) function and increases the trafficking of β-amyloid (Aβ) in monolayer cells. |
|
V126522 | 4-TCPA | 4-TCPA is a potent VEGFR2 inhibitor. | |
|
V128538 | ALK-IN-31 | 3043840-25-8 | ALK-IN-31 is an orally effective ALK inhibitor (IC50: 1135 nM). |
|
V129056 | Anti-inflammatory agent 107 | Anti-inflammatory agent 107 is an orally effective anti-inflammatory drug. | |
|
V128964 | Anticancer agent 271 | Anticancer agent 271 (compound 5C) has antiproliferative activity against lung cancer cell line (A549), colon cancer cell line (Caco-2), and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM against A549 cells. | |
|
V129234 | API32 | 162320-41-4 | API32 is a potent Pin1 inhibitor. |
|
V129593 | ATM Inhibitor-7 | 3033712-80-7 | ATM Inhibitor-7 is a highly potent and selective inhibitor of the ataxia-telangiectasia mutant gene (ATM) with an IC50 value of 1.0 nM. |
|
V129596 | ATM-IN-12 | 2134096-50-5 | ATM-IN-12 is an ATM kinase inhibitor with an IC50 of 1.26 μM. |
|
V129597 | ATM-IN-13 | 3104731-13-4 | ATM-IN-13 is an orally effective selective ATM kinase inhibitor with a human IC50 value of 0.3 nM. |
|
V129598 | ATM-IN-2 | ATM-IN-2 is a highly selective, orally effective ATM inhibitor with an IC50 value of 4 nM. |
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