ATM ATR

ATM ATR

It is well known that ATM/ATR, which belong to the phosphatidyl inositol 3-kinase-like family of serine/threonine protein kinases (PIKKs), are key players in the mitotic DNA damage response (DDR), which mounts responses to single-stranded DNA (ssDNA) and DNA double-strand breaks (DSBs), respectively. Ionizing radiation activates the signal transduction pathways that cause cell cycle arrest at G1/S, S, and G2/M by activating the ATM.In response to DNA-damaging agents like ultraviolet radiation that cause hefty lesions, ATR is necessary for cell cycle arrest.

In order to stabilize stalled replication forks, repair damaged DNA, and stop the cell cycle from continuing, ATM/ATR phosphorylate a wide range of targets upon activation. This helps to ensure cell survival and protect the integrity of the genome. The cell cycle checkpoints activated by ATM and ATR act as an active defense against tumorigenesis and genome instability in replicating cells.

ATM ATR related products

Structure Cat No. Product Name CAS No. Product Description
V70224 Mirin 299953-00-7 Mirin is a potent inhibitor of the Mre11-Rad50-Nbs1 (MRN) complex.
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