ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.The ERK pathway is activated by a wide range of stimuli, including as growth factors, cytokines, viral infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens. Ras stimulates c-Raf in the MAPK/ERK pathway, which is subsequently joined by mitogen-activated protein kinase kinase (also known as MKK, MEK, or MAP2K), followed by MAPK1/2 (see below).
Ras can be triggered by additional cues in addition to growth hormones through GRB2/SOS and receptor tyrosine kinases. Many transcription factors, including ELK1, and some downstream protein kinases are known to be activated by ERKs. Ras, c-Raf, and receptors like HER2 are known to cause disruption of the ERK pathway, which is frequently seen in malignancies.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52068 | Gardenin A (Gardenia (yellow) element A) | 21187-73-5 | Gardenin A is an orally bioavailable, synthetic PMF analog with neurotrophic effects on neurite outgrowth and neuronal differentiation. |
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V0466 | Ravoxertinib (GDC-0994; RG-7842) | 1453848-26-4 | Ravoxertinib (formerly known as GDC0994; RG7842) is a novel, potent, orally bioavailable inhibitor of extracellular signal-regulated kinase (ERK1/2) with potential antineoplastic activity. |
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V69818 | Glycinexylidide (GX) | 18865-38-8 | Glycinexylidide (GX) is the bioactive metabolite of Lidocaine. |
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V69105 | HA-1004 | 91742-10-8 | HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. |
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V104742 | JD118 | 315704-83-7 | JD118 is a JNK inhibitor. |
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V40505 | JWG-071 | 2250323-50-1 | JWG-071 is the first reported chemical probe selective for ERK5 kinase. |
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V4753 | KO-947 | 1695533-89-1 | KO-947 is a novel, potent and selective inhibitor of ERK1/2 kinases with potential usefulness in MAPK pathway dysregulated tumors. |
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V74708 | KRAS G12C inhibitor 61 | 2300967-40-0 | KRAS G12C inhibitor 61 (Example 3) inhibits ERK 1/2 phosphorylation in MIA PaCa-2 cells with IC50 of 9 nM. |
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V105136 | KRAS G12C inhibitor 69 | KRAS G12C inhibitor 69 (compound K09) is an inhibitor of mutant RAS protein KRASG12C with IC50 of 4.36 nM. | |
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V69775 | Larixol ((+)-Larixol) | 1438-66-0 | Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. |
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V69808 | Laxiflorin B | 165337-71-3 | Laxiflorin B is a Chinese herbal compound that can selectively inhibit ERK1/2 and has anti-tumor activity. |
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V80541 | Laxiflorin B-4 | Laxiflorin B-4 is a modified compound of Laxiflorin B with higher affinity for ERK1/2 and stronger tumor inhibitory activity. | |
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V69813 | MEK1 Derived Peptide Inhibitor 1 | 355367-87-2 | MEK1 Derived Peptide Inhibitor 1 is a bioactive peptide inhibitor. |
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V80769 | MHJ-627 | MHJ-627 is a potent ERK5 (MAPK7) inhibitor (IC50= 0.91 μM). | |
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V4122 | MK-8353 | 1184173-73-6 | MK-8353 (also known as SCH900353; SCH-900353) is a novel, potent, selective and orally bioavailable ERK inhibitor with anticancer activity. |
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V69819 | mSIRK (G-Protein βγ Binding Peptide) | 593267-11-9 | mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable (penetrable) activator of ERK1/2 with EC50 of 2.5-5 μM. |
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V87065 | mSIRK TFA | mSIRK TFA (G-Protein βγ Binding Peptide) is a cell-permeable ERK1/2 activator with EC50 of 2.5-5 μM. | |
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V80864 | Myristoyl-MEK1 Derived Peptide Inhibitor 1 | Myristoyl-MEK1 Derived Peptide Inhibitor 1 is the myristoylated form of MEK1 Derived Peptide Inhibitor 1. | |
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V87066 | Napyradiomycin B4 | Napyradiomycin B4 is a napyradiomycin derivative that inhibits RANKL-induced MEK-ERK signaling pathway. | |
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V69800 | Pamoic acid disodium (disodium pamoate; disodium acetylate; disodium pamoic acid salt) | 6640-22-8 | Pamoic acid disodium is a potent GPR35 agonist/activator with EC50 of 79 nM. |
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