A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.
The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.
Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54725 | Biotin-MeTz | 1802883-51-7 | Biotin-MeTz shiyi is a reagent for click chemistry with a terminal methyltetrazine group. |
|
V54624 | Biotin-PEG(4)-SS-Alkyne | 1260247-54-8 | Biotin-PEG(4)-SS-Alkyne is an alkyne-containing click chemistry reagent. |
|
V54518 | Biotin-PEG(4)-SS-Azide | 1260247-52-6 | Biotin-PEG(4)-SS-Azide is an azide-bearing reagent for click chemistry. |
|
V52575 | Biotin-PEG1-azide | 1204085-48-2 | Biotin-PEG1-azide is a cleavable ADC (Antibody-drug conjugate) linker containing 1 unit of PEG, which may be utilized to prepare ADC molecules. |
|
V52576 | Biotin-PEG1-NH2 | 811442-85-0 | Biotin-PEG1-NH2 is a cleavable ADC (Antibody-drug conjugate) linker containing 1 unit of PEG, which may be utilized to prepare ADC molecules. |
|
V79981 | Biotin-PEG2-methyl ethanethioate | Biotin-PEG2-methyl ethanethioate is a cleavable ADC (Antibody-drug conjugate) linker containing 2 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules. | |
|
V76148 | Biotin-PEG3-aldehyde | 889443-90-7 | Biotin-PEG3-aldehyde is a cleavable ADC (Antibody-drug conjugate) linker containing 3 PEG (polyethylene glycol) units, which may be utilized to prepare ADC molecules. |
|
V76122 | Biotin-PEG3-Me-Tet | 2143968-06-1 | Biotin-PEG3-Me-Tet is an ADC (Antibody-drug conjugate) Linker containing 3 PEG (polyethylene glycol) units. |
|
V53282 | Biotin-PEG4-MeTz | 1962919-31-8 | Biotin-PEG4-MeTz is a reagent for click chemistry containing a terminal methyltetrazine group that reacts with trans-cyclooctene. |
|
V52574 | Biotin-PEG4-PFP ester | 1334172-58-5 | Biotin-PEG4-PFP ester is a cleavable ADC (Antibody-drug conjugate) linker containing 4 PEG (polyethylene glycol) units, which may be utilized to prepare ADC molecules. |
|
V78456 | Biotin-PEG4-SS-azide | Biotin-PEG4-SS-azide is a degradable, biotin-labeled ADC linker used to synthesize ADCs. | |
|
V52573 | Biotin-sar-oh | 154024-76-7 | Biotin-sar-oh is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V54536 | Biotin-TEG-ATFBA | 1264662-85-2 | Biotin-TEG-ATFBA is a reagent for click chemistry containing a perfluorophenyl azide group. |
|
V103957 | Bis-PEG30-NHS ester | Bis-PEG30-NHS ester is a non-degradable ADC linker containing 30 PEG units for use in the synthesis of antibody conjugates (ADCs). | |
|
V52734 | Bis-SS-C3-NHSester | 98604-88-7 | Bis-SS-C3-NHS ester is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V52733 | Bis-SS-C3-sulfo-NHS ester | 98604-89-8 | Bis-SS-C3-sulfo-NHS ester is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V56377 | Bis-sulfone-PEG3-Azide | 1802908-01-5 | Bis-sulfone-PEG3-Azide is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V52861 | Boc-C14-COOH | 843666-27-3 | Boc-C14-COOH is a non-cleavable (non-degradable) ADC linker, used for the synthesis of ADCs (antibody-drug conjugates). |
|
V52664 | Boc-C16-COOH | 843666-40-0 | Boc-C16-COOH is a non-cleavable (non-degradable) ADC linker, used for the synthesis of ADCs (antibody-drug conjugates). |
|
V54667 | Boc-Cystamine-Poc | 2171512-56-2 | Boc-Cystamine-Poc (Compound H4) is a reagent for click chemistry with a cystamine structural unit. |
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