A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.
The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.
Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52673 | SPDP-sulfo | 121115-30-8 | SPDP-sulfo is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V52921 | SPDV | 317331-86-5 | SPDV is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized in study/research of cancer or B cell growth/proliferation diseases. |
|
V53280 | Spermine(N3BBB) | 1190203-80-5 | Spermine(N3BBB) is an azide-bearing reagent for click chemistry that may be utilized in a variety of biochemical studies. |
|
V93187 | STI-8811 drug-linker | 2833733-13-2 | STI-8811 Drug Linker is a linker that can be used to synthesize the ADC molecule STI-8811. |
|
V52627 | Succinic anhydride-13C2 | 67519-25-9 | Succinic anhydride-13C2 is 13C (carbon 13) labelled Succinic anhydride. |
|
V52626 | Succinic anhydride-d4 | 14341-86-7 | Succinic anhydride-d4 is the deuterium labelled form of Succinic anhydride. |
|
V54591 | Sulfo DBCO-PEG3-acid | 2566404-75-7 | Sulfo DBCO-PEG3-acid is a reagent for click chemistry bearing an azide (N3) moiety. |
|
V54694 | Sulfo DBCO-TFP Ester | 2268816-76-6 | Sulfo DBCO-TFP Ester is a water-soluble, sulfo-containing click chemistry reagent. |
|
V54502 | Sulfo-LC-SPDP | 150244-18-1 | Sulfo-LC-SPDP is a heterobifunctional cross-linker, and the sulfhydryl group of Sulfo-LC-SPDP can be cleaved. |
|
V54627 | Sulfo-SIAB | 106145-13-5 | Sulfo-SIAB is a nondegradable monovalent bilinker. |
|
V54593 | Sulfo-SIAB sodium | 144650-93-1 | Sulfo-SIAB sodium is a nondegradable monovalent double linker. |
|
V54544 | Sulfo-SMPB sodium | 92921-26-1 | Sulfo-SMPB sodium is a non-cleavable (non-degradable) heterobifunctional chemical cross-linker containing N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing amine and sulfhydryl groups molecules are covalently bound. |
|
V54523 | Sulfo-SNPB | 1193111-37-3 | Sulfo-SNPB is a degradable linker used to prepare active antibody conjugate molecules (ADC). |
|
V54504 | Sulfo-SPP | 452072-27-4 | Sulfo-SPP is a heterobifunctional cross-linking agent, and the sulfhydryl group of Sulfo-SPP can be cleaved. |
|
V54508 | Sulfo-SPP sodium | 452072-24-1 | Sulfo-SPP sodium is a heterobifunctional cross-linking agent, and the sulfhydryl group of Sulfo-SPP sodium can be cleaved. |
|
V52852 | tans-4-Hydroxy-D-proline hydrochloride | 142347-81-7 | tans-4-Hydroxy-D-proline HCl is a non-cleavable (non-degradable) ADC linker, used for the synthesis of ADCs (antibody-drug conjugates). |
|
V52853 | tans-4-Hydroxy-D-proline methyl ester hydrochloride | 481704-21-6 | tans-4-Hydroxy-D-proline methyl ester HCl is a non-cleavable (non-degradable) ADC linker used to synthesize ADCs (antibody-drug conjugates). |
|
V54539 | TCO-GK-PEG4-NHSester | 2307311-19-7 | TCO-GK-PEG4-NHS ester is an ADC (Antibody-drug conjugate) Linker that may be utilized to prepare [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. |
|
V76126 | TCO-NHS Ester (axial) | 1610931-22-0 | TCO-NHS Ester axial is a reagent for click chemistry that could be utilized as a building block in amine reactions. |
|
V76109 | TCO-PEG3-maleimide | 1609659-01-9 | TCO-PEG3-maleimide (TCO-PEG3-NEM) is a reagent for click chemistry. |
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