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ADC Linker

ADC Linker

A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.

The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.

Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.

ADC Linker related products

Structure Cat No. Product Name CAS No. Product Description
Me-Tet-PEG4-NH2 V76110 Me-Tet-PEG4-NH2 2055646-21-2 Me-Tet-PEG4-NH2 is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units.
Me-Tet-PEG4-NHBoc V76115 Me-Tet-PEG4-NHBoc 2143955-71-7 Me-Tet-PEG4-NHBoc is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units.
Me-Tet-PEG4-NHS V76111 Me-Tet-PEG4-NHS 2143968-22-1 Me-Tet-PEG4-NHS is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units.
Me-Tet-PEG5-COOH V76119 Me-Tet-PEG5-COOH 2143964-72-9 Me-Tet-PEG5-COOH is an ADC (Antibody-drug conjugate) Linker containing 5 PEG (polyethylene glycol) units.
Me-Tet-PEG5-NHS V76135 Me-Tet-PEG5-NHS 2096446-25-0 Me-Tet-PEG5-NHS is an ADC (Antibody-drug conjugate) Linker containing 5 PEG (polyethylene glycol) units.
Me-Tet-PEG8-Maleimide V76124 Me-Tet-PEG8-Maleimide 2143968-05-0 Me-Tet-PEG8-Maleimide is an ADC (Antibody-drug conjugate) Linker containing 8 PEG (polyethylene glycol) units.
Me-Tet-PEG8-NH2 hydrochloride V80754 Me-Tet-PEG8-NH2 hydrochloride Me-Tet-PEG8-NH2 ( HCl) is an ADC (Antibody-drug conjugate) Linker containing 2 PEG (polyethylene glycol) units.
Me-Tet-PEG8-NHBoc V76138 Me-Tet-PEG8-NHBoc 2143968-21-0 Me-Tet-PEG8-NHBoc is an ADC (Antibody-drug conjugate) Linker containing 8 PEG (polyethylene glycol) units.
Me-Tet-PEG9-COOH V76144 Me-Tet-PEG9-COOH 2143964-70-7 Me-Tet-PEG9-COOH is an ADC (Antibody-drug conjugate) Linker containing 9 PEG (polyethylene glycol) units.
Me-Tet-PEG9-NHS V76117 Me-Tet-PEG9-NHS 2143955-78-4 Me-Tet-PEG9-NHS is an ADC (Antibody-drug conjugate) Linker containing 9 PEG (polyethylene glycol) units.
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc V76147 Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc 894096-02-7 Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare active antibody conjugated molecules (ADC).
MeO-PEG-alkyne (MW 750Da) V80741 MeO-PEG-alkyne (MW 750Da) MeO-PEG-alkyne (MW 750Da) is an alkyne-containing click chemistry reagent.
Methyl 1-Boc-azetidine-3-carboxylate V52871 Methyl 1-Boc-azetidine-3-carboxylate 610791-05-4 Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable (non-degradable) ADC linker used to synthesize ADCs (antibody-drug conjugates).
Methyl 1-Cbz-azetidine-3-carboxylate V52868 Methyl 1-Cbz-azetidine-3-carboxylate 757239-60-4 Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable (non-degradable) ADC linker, used for the synthesis of ADCs (antibody-drug conjugates).
Methyl azetidine-3-carboxylate hydrochloride V52864 Methyl azetidine-3-carboxylate hydrochloride 100202-39-9 Methyl azetidine-3-carboxylate ( HCl) is a non-cleavable (non-degradable) ADC linker used for the synthesis of active antibody conjugated molecules (ADCs).
Methylamino-PEG3-benzyl V80454 Methylamino-PEG3-benzyl Methylamino-PEG3-benzyl is an amino PEG linker.
MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D V52617 MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D 2222445-87-4 MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC).
Methyltetrazine-amido-N-bis(PEG4-acid) V54628 Methyltetrazine-amido-N-bis(PEG4-acid) 2639395-39-2 Methyltetrazine-amido-N-bis(PEG4-acid) is a reagent for click chemistry bearing an azide (N3) moiety.
Methyltetrazine-PEG12-acid V80764 Methyltetrazine-PEG12-acid Methyltetrazine-PEG12-acid is a polyethylene glycol click chemistry reagent containing tetrazine groups.
Methyltetrazine-PEG12-NHS ester V80765 Methyltetrazine-PEG12-NHS ester Methyltetrazine-PEG12-NHS ester is a reagent for click chemistry bearing an azide (N3) moiety.
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