yingweiwo
  1. Home
  2. Products
  3. Signaling Pathways
  4. ADC Related
  5. ADC Linker

ADC Linker

ADC Linker

A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.

The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.

Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.

ADC Linker related products

Structure Cat No. Product Name CAS No. Product Description
Mc-Gly-Gly-Phe-Gly-PAB-OH TFA (Mc-GGFG-PAB-OH TFA) V76783 Mc-Gly-Gly-Phe-Gly-PAB-OH TFA (Mc-GGFG-PAB-OH TFA) Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) TFA is a cleavable ADC (Antibody-drug conjugate) linker that may be utilized to prepare active antibody conjugated molecules (ADC).
MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH V56383 MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH 1802520-40-6 MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare active antibody conjugated molecules (ADC).
Mc-Leu-Gly-Arg V79587 Mc-Leu-Gly-Arg 2639874-49-8 Mc-Leu-Gly-Arg is a cleavable ether linker that can be used for antibody conjugation active molecules (ADC) research.
MC-PEG2-C2-NHS ester V54619 MC-PEG2-C2-NHSester 1263044-56-9 MC-PEG2-C2- NHS ester is a non-degradable linker containing 2 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
MC-PEG2-NH2 V56380 MC-PEG2-NH2 640267-62-5 MC-PEG2-NH2 is a degradable (non-cleavable (non-degradable)) ADC bridge used for the synthesis of antibody active molecule conjugates (ADCs).
Mc-Val-Ala-PAB V25127 Mc-Val-Ala-PAB 1870916-87-2 Mc-Val-Ala-PAB is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare active antibody conjugated molecules (ADC).
MC-Val-Cit-PAB V5177 MC-Val-Cit-PAB 159857-80-4 MC-Val-Cit-PAB is a novel cathepsin cleavable ADC linker that is utilized for the synthesis of antibody-drug conjugate (ADC) such as some of the FDA approved ADC drugs including brentuximab vedotin.
MC-Val-Cit-PAB-NH-C2-NH-Boc V52695 MC-Val-Cit-PAB-NH-C2-NH-Boc 1616727-22-0 MC-Val-Cit-PAB-NH-C2-NH-Boc is an ADC (Antibody-drug conjugate) Linker that can be degraded by cathepsin and may be utilized to prepare ADC molecules.
MC-VC-PAB-NH2 TFA V54682 MC-VC-PAB-NH2 TFA 1616727-21-9 MC-VC-PAB-NH2 TFA is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare Antibody-drug conjugates (ADC).
mc-vc-PAB-PBD V85092 mc-vc-PAB-PBD 2088364-36-5
MCC V34833 MCC 104676-09-7 MCC is a non-cleavable (non-degradable) ADC linker that may be utilized to prepare ADCs, like MCC-DM1.
Me-PMeOx(100)-N3 (MW 8.5kDa) V80745 Me-PMeOx(100)-N3 (MW 8.5kDa) Me-PMeOx(100)-N3 (MW 8.5kDa) is a reagent for click chemistry.
Me-PMeOx(50)-N3 (MW 4.3kDa) V80746 Me-PMeOx(50)-N3 (MW 4.3kDa) Me-PMeOx(50)-N3 (MW 4.3kDa) is a reagent for click chemistry.
Me-Tet-PEG2-COOH V76134 Me-Tet-PEG2-COOH 2741759-99-7 Me-Tet-PEG2-COOH is an ADC (Antibody-drug conjugate) Linker containing 2 PEG (polyethylene glycol) units.
Me-Tet-PEG2-NHS V76143 Me-Tet-PEG2-NHS 2740357-12-2 Me-Tet-PEG2-NHS is an ADC (Antibody-drug conjugate) Linker containing 2 PEG (polyethylene glycol) units.
Me-Tet-PEG3-Maleimide V76125 Me-Tet-PEG3-Maleimide 2141976-31-8 Me-Tet-PEG3-Maleimide is an ADC (Antibody-drug conjugate) Linker containing 3 PEG (polyethylene glycol) units.
Me-Tet-PEG3-NH2 V79991 Me-Tet-PEG3-NH2 Me-Tet-PEG3-NH2 is an ADC (Antibody-drug conjugate) Linker containing 3 PEG (polyethylene glycol) units.
Me-Tet-PEG3-NHBoc V76112 Me-Tet-PEG3-NHBoc 2141976-32-9 Me-Tet-PEG3-NHBoc is an ADC (Antibody-drug conjugate) Linker containing 3 PEG (polyethylene glycol) units.
Me-Tet-PEG4-COOH V76127 Me-Tet-PEG4-COOH 2141976-30-7 Me-Tet-PEG4-COOH is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units.
Me-Tet-PEG4-Maleimide V76114 Me-Tet-PEG4-Maleimide 1715913-76-0 Me-Tet-PEG4-Maleimide is an ADC (Antibody-drug conjugate) Linker containing 4 PEG (polyethylene glycol) units.
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: sales@invivochem.com Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

linkedin facebook
Contact Us
Home Product Cart Member