ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
![(rac)-Exatecan Intermediate 1 (4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-F]吲嗪-3,6,10(4H)-三酮)](http://www.invivochem.com/upload/1124/hy-42487a.png)
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V54461 | (rac)-Exatecan Intermediate 1 (4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-F]indolizine-3,6,10(4H)-trione ) | 102978-40-5 | (rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1. |
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V54462 | (S)-Seco-Duocarmycin SA | 152785-82-5 | (S)-Seco-Duocarmycin SA is a DNA alkylating agent that works as the toxin part of the antibody active molecular conjugate (ADC cytotoxin). |
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V84522 | 10NH2-11F-Camptothecin TFA | 2873461-64-2 | |
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V54471 | 17-AEP-GA | 75747-23-8 | 17-AEP-GA is an HSP90 antagonist that effectively inhibits glioblastoma cell proliferation/growth, survival, migration and invasion. |
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V54478 | 17-GMB-APA-GA | 256337-10-7 | 17-GMB-APA-GA is an ADC Cytotoxin. |
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V52521 | 2',3'-cGAMP-C2-SH | 2133823-39-7 | 2',3'-cGAMP-C2-SH is an ADC Cytotoxin disclosed in patent US20210015941, Example 24. |
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V92337 | 2-Azidoethyl β-D-lactoside | 230286-11-0 | beta-Lac-EO-N3 is a click chemistry reagent. |
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V52959 | 7-Aminomethyl-10-methyl-11-fluorocamptothecin | 2378616-23-8 | 7-Aminomethyl-10-methyl-11-fluoro camptothecin is the toxin molecule of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin , which may be utilized to prepare camptothecin antibody conjugate drugs. |
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V77314 | 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA | 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA is the toxin molecule of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin, which may be utilized to prepare camptothecin antibody drug conjugates (ADC). | |
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V54485 | 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) | 2873460-17-2 | 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) is an analog of Camptothecin . |
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V92074 | 7-MAD-MDCPT | 765871-81-6 | 7-MAD-MDCPT, a camptothecin analog, is the active moiety in antibody-drug conjugates (ADCs). |
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V54479 | Ac-Exatecan | 2922852-48-8 | Ac-Exatecan is acetylated Exatecan . |
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V34722 | Aeruginosin 865 | 1611990-01-2 | Aeruginosin 865 was extracted from the terrestrial cyanobacteria Nostoc sp. |
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V53480 | Agrochelin | 247115-74-8 | Agrochelin is an alkaloid cytotoxic antibiotic produced by fermentation of the marine Agrobacterium species. |
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V34676 | Aldoxorubicin hydrochloride (INNO-206 hydrochloride; DOXO-EMCH hydrochloride) | 1361563-03-2 | Aldoxorubicin (INNO-206) HCl (is the albumin-bound precursor of doxorubicin (a DNA topoisomerase II inhibitor) and is released from albumin under acidic conditions. |
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V51973 | Aminohexylgeldanamycin (AHGDM) | 485395-71-9 | Aminohexylgeldanamycin (AHGDM), an analogue of geldanamycin, is a heat shock protein 90 (HSP90) inhibitor. |
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V51974 | Aminohexylgeldanamycin hydrochloride (AHGDM hydrochloride) | 1146534-45-3 | Aminohexylgeldanamycin (AHGDM) HCl, an analogue of Geldanamycin, is a heat shock protein 90 (HSP90) inhibitor. |
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V106380 | Anti-DM1 antibody(14E3) (Rabbit mAb) | Anti-DM1 Antibody (14E3) (rabbit mAb) is a rabbit IgG antibody against DM1 and can be used in ELISA experiments without being affected by species differences. | |
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V84314 | AXC-666 | 313350-30-0 | |
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V54477 | Azonafide-PEABA | 2752193-52-3 | Azonafide-PEABA is a cytotoxic active molecule. |
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