ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54476 | Tubulysin IM-2 | 1032072-50-6 | Tubulysin IM-2 is a microtubule/tubulin inhibitor that can be used as ADC Cytotoxin and anti-microtubule toxins for ADC synthesis. |
|
V54489 | Tubulysin IM-3 | 1639986-05-2 | Tubulysin IM-3 is a microtubule/tubulin inhibitor that can be used as ADC Cytotoxin and anti-microtubule toxins for ADC synthesis. |
|
V51220 | γ-Amanitin | 21150-23-2 | ADC cytotoxin |
|
V51222 | ε-Amanitin | 21705-02-2 | ADC cytotoxin |
|
V11901 | Auristatin F | 163768-50-1 | Auristatin F is anMMAF analogused as a cytotoxin in ADC (Antibody-drug conjugates) synthesis, acting as highlypotent antimitotic agent/tubulin inhibitor and anticancer agent thatinhibits tubulin polymerization. |
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V92650 | (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid | 949023-16-9 | |
|
V17212 | Mertansine (DM1) | 139504-50-0 | Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with an SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. |
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