Protein kinase C (PKC) is a family of protein kinase enzymes that play a role in regulating the activity of other proteins by phosphorylating the hydroxyl groups on serine and threonine amino acid residues. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes are crucial components of numerous signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V16673 | TPPB | 497259-23-1 | TPPB is a novel, potent and cell-permeable benzolactam-derived protein kinase C (PKC) activator (Ki = 11.9 nM) wuth neuroprotective effects. |
|
V16477 | Verbascoside (Acteoside; Kusaginin; TJC160) | 61276-17-3 | Verbascoside(Acteoside; Kusaginin; TJC-160), a natural productisolated from Lantana camara,is novel and potent inhibitor of the Oligomerization of Pneumolysin. |
|
V33226 | VTX-27 | 1321924-70-2 | VTX-27 (VTX27) is a novel, potent and selective protein kinase C θ (PKC θ) inhibitor with Ki values of 0.08 nM and 16 nM for PKC θ and PKC δ. |
|
V67541 | ζ-Stat (NSC37044) | 3316-02-7 | ζ-Stat (NSC37044) is a specific and atypical inhibitor of PKC-ζ with IC50 of 5 μM. |
|
V67540 | ζ-Stat trisodium (NSC37044 trisodium) | 31894-34-5 | ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical inhibitor of PKC-ζ with IC50 of 5 μM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
