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MicroRNA

MicroRNA

MicroRNAs (miRNAs) are a class of small, naturally occurring non-coding RNAs that control post-transcriptional gene expression to regulate cellular functions, development, cell differentiation, and homeostasis. They are about 22 nucleotides long. Since microRNAs control cell differentiation, proliferation, and apoptosis, they are crucial for the development of embryos, cells, and tissues, which explains their significance in human reproduction. Meanwhile, it has been discovered that abnormal miRNA expression or function is closely linked to the occurrence or progression of a number of human diseases, including cancers. MiRNAs are emerging as novel biomolecular targets for chemical-biological studies, including regulation and detection, given their significant roles in physiology and pathology.
The production of miRNAs involves a number of steps. The canonical biogenesis pathway, which produces the majority of miRNAs, involves RNA polymerase II transcription to create a primary transcript (pri-miRNA) and microprocessor complex cleavage to create a hairpin precursor miRNA (pre-miRNA) in the nucleus.Following export into the cytoplasm, the enzyme Dicer cleaves the pre-miRNA to produce a double-stranded RNA duplex. AGO proteins in the RNA-induced silencing complex (RISC) are guided in their binding to the 3' untranslated region (UTR) to either repress protein translation or promote mRNA degradation by the mature miRNA, which is only one strand of the double-stranded RNA duplex.There are non-canonical microprocessor- or Dicer-independent miRNA biogenesis pathways in addition to the canonical miRNA biogenesis pathways. There have been reports of miRNAs promoting gene expression, despite the fact that miRNAs are primarily involved in the down-regulation of gene expression. Furthermore, in a particular cell type, the relationships between miRNAs and their targets are not always 1:1. In actuality, a single miRNA may control a large number of mRNA targets, and vice versa, a single mRNA target may also be controlled by a large number of miRNAs.

MicroRNA related products

Structure Cat No. Product Name CAS No. Product Description
aof-MIR12147 V129209 aof-MIR12147 aof-MIR12147 is an asparagus miRNA.
Benzazepinoquinoline-spermine V109095 Benzazepinoquinoline-spermine 2250121-20-9 Benzoazaheptacyclic heptenquinoline-spermine (compound PA-3) is a highly efficient pre-miR-372 complex forming agent that can specifically inhibit its Dicer-mediated processing, with an IC₅₀ value of 0.58 μM.
Camptothecin-d5 V51641 Camptothecin-d5 1329616-37-6 Camptothecin-d5 is the deuterated form of camptothecin.
Cobomarsen sodium V90327 Cobomarsen sodium 1848257-85-1 Cobomarsen sodium is an oligonucleotide inhibitor of miR-155 and can be used in the study of B-cell lymphoma.
Cy3 MicroRNA Antagomir Negative Control V105322 Cy3 MicroRNA Antagomir Negative Control Cy3 MicroRNA Antagomir Negative Control is a Cy3 labeled microRNA antagomir negative control.
Cy5-MicroRNA Mimic Negative Control V111466 Cy5-MicroRNA Mimic Negative Control The Cy5-tagged microRNA mimic negative control is a microRNA mimic negative control with a Cy5 tag.
Dimovarsen V133871 Dimovarsen 2568631-54-7 Dimovarsen is an oligonucleotide and a microRNA-132 inhibitor that can be used to study heart failure.
Dimovarsen sodium V133872 Dimovarsen sodium Dimovarsen sodium is an oligonucleotide and a microRNA-132 inhibitor that can be used to study heart failure.
Eldocasiran sodium V79283 Eldocasiran sodium Eldocasiran sodium is a micro-ARN-193a-3p analog, and Eldocasir has anti-cancer effect and may be utilized in cancer-related research.
FAM-MicroRNA Inhibitor Negative Control V135742 FAM-MicroRNA Inhibitor Negative Control The FAM-MicroRNA Inhibitor Negative Control is a negative control for FAM-labeled microRNA inhibitors.
FAM-MicroRNA Mimic Negative Control V135743 FAM-MicroRNA Mimic Negative Control FAM-MicroRNA Mimic Negative Control is a negative control of FAM-labeled microRNA mimics.
Farabursen V116957 Farabursen 2953012-32-1 Farabursen (RGLS8429) is an oligonucleotide used to study autosomal dominant polycystic kidney disease.
Farabursen sodium V116869 Farabursen sodium 2921918-19-4 Farabursen (RGLS8429) is an oligonucleotide used to study autosomal dominant polycystic kidney disease.
Farabursen sodium scrambled negative control V135790 Farabursen sodium scrambled negative control The Farabursen sodium scrambled negative control is a negative control for Farabursen sodium with a scrambled sequence.
hsa-let-7a-2-3p agomir V137536 hsa-let-7a-2-3p agomir hsa-let-7a-2-3p agomir is a chemically modified double-stranded miRNA mimic. Its mature miRNA strand is modified with two thiophosphate groups at the 5' end, four thiophosphate groups at the 3' end, a cholesterol group at the 3' end, and the full-length nucleotide is modified with a 2'-methoxy group.
hsa-let-7a-2-3p antagomir V89464 hsa-let-7a-2-3p antagomir Hsa-let-7a-2-3p antagomir is a complementary single strand of mature miRNA that has undergone special chemical modification.
hsa-let-7a-2-3p inhibitor V89548 hsa-let-7a-2-3p inhibitor hsa-let-7a-2-3p inhibitor is a complementary single strand of mature miRNA that has been fully methoxylated.
hsa-let-7a-2-3p mimic V89468 hsa-let-7a-2-3p mimic hsa-let-7a-2-3p mimic is a chemically synthesized miRNA mimic that can mimic endogenous miRNA, upregulate miRNA activity, and is used in gain-of-function studies.
hsa-let-7a-3p agomir V137537 hsa-let-7a-3p agomir hsa-let-7a-3p agomir is a chemically modified double-stranded miRNA mimic. Its mature miRNA strand is modified with two thiophosphate groups at the 5' end, four thiophosphate groups at the 3' end, a cholesterol group at the 3' end, and the full-length nucleotide is modified with 2'-methoxy.
hsa-let-7a-3p antagomir V137538 hsa-let-7a-3p antagomir hsa-let-7a-3p antagomir is a chemically modified oligonucleotide that can hybridize with mature miRNAs.
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