Aurora Kinase

Aurora Kinase

The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.

While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.

Aurora Kinase related products

Structure Cat No. Product Name CAS No. Product Description
V0362 TAK-901 934541-31-8 TAK-901 (TAK901) is a novel and potent inhibitor of Aurora A/B kinases with potential antitumor activity.
V0358 TCS7010 (Aurora A Inhibitor I) 1158838-45-9 TCS 7010 (Aurora A Inhibitor I; TCS-7010 ) is a novel, potent, and highly selective inhibitor of Aurora A kinase-AAK with potential antitumor activity.
V0344 Tozasertib (VX680; MK0457) 639089-54-6 Tozasertib (formerly VX-680; MK-0457) is a novel and potent pan-Aurora kinase (AK) inhibitor with potential anticancer activity.
V0346 ZM 447439 331771-20-1 ZM 447439 (ZM-447439) is a novel, potent, selective and ATP-competitive inhibitor of Aurora A and Aurora B with potential antitumor activity.
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