Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V121168 | (+)-BAY-7081 | (+)-BAY-7081 is an optical isomer of BAY-7081. | |
|
V0787 | S- (+)-Rolipram (ME-3167; SB95952; ZK-62711) | 85416-73-5 | S-(+)-Rolipram, theS-isomer of rolipram (ME3167;SB-95952; ZK62711), isa potent phosphodiesterase PDE4-inhibitor with potent anti-inflammatory and anti-depressant activity. |
|
V121225 | (±)-BAY-7081 | (±)-BAY-7081 is the racemic mixture of BAY-7081. | |
|
V128139 | Acetylvardenafil | 1261351-28-3 | Acetylvardenafil is a novel analogue of vardenafil. |
|
V128416 | AGS-16C3F | AGS-16C3F is an antibody-drug conjugate (ADC) that targets ENPP3. | |
|
V129640 | ATX inhibitor 25 | 2951100-44-8 | ATX inhibitor 25 is an orally effective autosecretin inhibitor with an IC50 value of 1.08 nM. |
|
V129644 | ATX-IN-1 | ATX-IN-1 is an ATX inhibitor (IC50 = 0.7 nM) with anti-inflammatory activity. | |
|
V129645 | ATX-IN-2 | 3076224-81-9 | ATX-IN-2 is an orally effective and potent ATX inhibitor with an IC50 value of 3.27 nM. |
|
V51292 | Carbazeran citrate | 153473-94-0 | Carbazeran (citrate) is a potent phosphodiesterase inhibitor and aldehyde oxidase substrate. |
|
V133222 | Davalomilast | 2379980-45-5 | Davalomilast is a PDE4 inhibitor with anti-inflammatory properties. |
|
V51451 | Deltasonamide 1 TFA | 2235358-73-1 | Deltasonamide 1 TFA is a PDE6δ-KRas dye. |
|
V133537 | Desmethyl thiosildenafil | 479073-86-4 | Desmethyl thiosildenafil is a type 5 phosphodiesterase (PDE5) inhibitor[1]. |
|
V37637 | Enpp-1-IN-1 | 2289728-58-9 | Enpp-1-IN-1 is a potent and specific enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor. |
|
V135115 | Enpp-1-IN-26 | 2848714-91-8 | Enpp-1-IN-26 is an ENPP1 inhibitor with an IC50 value of 0.188 μM. |
|
V135116 | Enpp-1-IN-30 | Enpp-1-IN-30 is an ENPP1 inhibitor with high oral bioavailability, and its human IC50 value is 13.1 nM. | |
|
V135117 | Enpp-1-IN-31 | Enpp-1-IN-31 is an ENPP1 inhibitor with an IC50 of <20 nM (using cGAMP as a substrate). | |
|
V51610 | FCPR-03 | 1917347-65-9 | FCPR03 is a potent and specific phosphodiesterase 4 (PDE4) conjugate with IC50s of 60 nM, 31 nM and 47 nM for the PDE4 catalytic domain, PDE4B1 and PDE4D7, respectively. |
|
V51611 | FCPR-16 | PDE4 inhibitor | |
|
V136877 | GPR61 Inverse agonist 3 | GPR61 Inverse Agonist 3 is a selective GPR61 inverse agonist that can cross the blood-brain barrier. Its human IC50 value is 4.0 nM, its mouse IC50 value is 8.8 nM, its human Ki value is 0.34 nM, and its mouse Ki value is 1.1 nM. | |
|
V136927 | Griseolic acid B | 98890-01-8 | Greyic acid B (7′-deoxygreic acid) has inhibitory activity against cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17], with an IC50 of 0.16 μM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
