Leukotrienes, lipoxins, and neuroprotectins are just a few of the eicosanoids and docosanoids that are produced as a result of the metabolism of arachidonic and docosahexaenoic acid by the family of enzymes known as lipoxygenases (LOXs). These enzymes are either involved in oxidative stress and cell death mechanisms or in cell protection, depending on the redox state of the cells and other milieu conditions. Lipoxygenases are lipid peroxidizing enzymes that may be targets for pharmacological treatment because they are involved in the pathogenesis of inflammatory and hyperproliferative diseases.
According to where arachidonate is oxygenated, lipoxygenases are categorized as 5-, 8-, 9-, 11-, 12-, and 15-LOX. 5-LOX, 8-LOX, 12-LOX, and 15-LOX are the most prevalent animal LOXs, whereas 5-LOX and 15-LOX are the most prevalent plant LOXs. When it comes to the production of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators, 5-LOX is the most prevalent isoform.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V3027 | ML355 | 1532593-30-8 | ML355 is the first selective, orally bioavailable 12-LOX inhibitor which displays high potency (IC50 of 0.34 μM) against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. |
|
V73499 | Patulitrin | 19833-25-1 | Patulitrin has the effect of scavenging DPPH free radicals. |
|
V5076 | PD146176 (NSC168807) | 4079-26-9 | PD146176 (alfo known as NSC168807) is a novel and potent 15-Lipoxygenase (15-LO) inhibitor which inhibits rabbit reticulocyte 15-LO with a Kiof 197 nM. |
|
V73507 | Picrinine | 4684-32-6 | Picrinine is an Akuammiline alkaloid extracted from the leaves of Alstonia scholaris. |
|
V73502 | Plathymenin | 492-12-6 | Plathymenin is a flavonoid that can be extracted from Nepalese propolis. |
|
V2108 | Zileuton (A 64077; Abbott 64077) | 111406-87-2 | Zileuton (also known as A-64077;Abbott 64077; ZYFLO; ZYFLO CR)is a novel, potent and orally bioactive inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, it was introduced in 1996 to decrease the symptoms of asthma. |
|
V29841 | β-Boswellic acid | 631-69-6 | β-Boswellic acid is extracted from the gum resin of Boswellia serrate. |
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