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Xanthine Oxidase

Xanthine Oxidase

Xanthine oxidase (XO), a multifunctional molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and then the subsequent reduction of oxygen at the flavin center with the production of reactive oxygen species, either superoxide anion radicals or hydrogen peroxide.

The purine catabolism pathway's key enzyme, xanthine oxidase, has been linked indirectly to a number of pathological conditions, including cancer, diabetes, and metabolic syndrome, as well as directly to the pathogenesis of gout. Gout, cancer, inflammation, and oxidative damage may all be treated therapeutically by selectively inhibiting xanthine oxidase.

Xanthine Oxidase related products

Structure Cat No. Product Name CAS No. Product Description
2H-1-苯并吡喃-3,5,7-三醇，2-（3,4-二羟基苯基）-3,4-二氢- V107913 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro- 13392-26-2 (+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM found in Plantago asiatica (Psyllium).
5,6,7-Trihydroxy-4'-methoxyflavone V111094 5,6,7-Trihydroxy-4'-methoxyflavone 6563-66-2 5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-methylbaicalein) is a flavonoid compound and a weak inhibitor of xanthine oxidase.
5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione V127032 5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione 114590-95-3 5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione is a xanthine oxidase (XO) inhibitor found in hemoglobin algae.
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside V127433 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside 6-Methoxypurine-9-β-D-5'(R)-C-methylriboside is a hypoxanthine analogue.
7,8,3′,4′-Tetrahydroxyflavone V71967 7,8,3′,4′-Tetrahydroxyflavone 3440-24-2 7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor (antagonist) with IC50 of 10.488 µM.
Amflutizole V87760 Amflutizole 82114-19-0 Amflutizole (LY-141894) is a xanthine oxidase inhibitor.
Angexostat V128834 Angexostat 2640653-91-2 Angexostat is a xanthine oxidase inhibitor.
Aurantiamide benzoate V71969 Aurantiamide benzoate 150881-02-0 Aurantiamide benzoate is a naturally occurring compound extracted from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata.
Baicalein 6-O-glucoside V71981 Baicalein 6-O-glucoside 28279-72-3 Baicalein 6-O-glucoside is the glucuronidation metabolite of Baicalein.
Baicalein hydrate V87758 Baicalein hydrate 352000-07-8 Baicalein hydrate (5,6,7-Trihydroxyflavone hydrate) is a xanthine oxidase inhibitor with IC50 value of 3.12 μM.
BOF-4272 V87761 BOF-4272 142181-44-0 BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor.
Hydroxyakalone V137682 Hydroxyakalone 182056-35-5 Hydroxyakalone is an inhibitor of xanthine oxidase (XOD, EC 1.2.3.2) with an IC50 of 4.6 μM.
NARS-3′ V140988 NARS-3′ 2702589-46-4 NARS-3′ is an orally effective reversible xanthine oxidase (XO) inhibitor with an IC50 value of 21.01 μM.
Neosakuranin V111305 Neosakuranin 31187-54-9 Neospermone is a flavonoid compound that can be extracted from the bark of cherry (P. cerasus) and rowan (Sorbus commixta).
Oxypurinol-13C,15N2 V87762 Oxypurinol-13C,15N2 Oxypurinol-13C,15N2 is 15N and 13C labeled Oxypurinol.
Procyanidin B2 3′-O-gallate V112360 Procyanidin B2 3′-O-gallate 73086-04-1 Rhodiola rosea extract proanthocyanidin B2 3′-O-gallate (B2-3′-G) is a potent xanthine oxidase (XO) inhibitor (IC50 = 24.24 μM, Ki = 6.16 μM).
Smilaxchinoside A V145064 Smilaxchinoside A 935530-84-0 Smilaxchinoside A is an orally effective steroidal glycoside found in the roots of Smilax riparia.
Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) V85211 Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) 18103-42-9
URAT1&XO inhibitor 1 V71978 URAT1&XO inhibitor 1 2669726-78-5 URAT1&XO inhibitor 1 (compound 29) is a dual (bifunctional) inhibitor of URAT1 (IC50=~10μM) and xanthine oxidase (IC50=1.01μM).
Xanthine oxidase-IN-11 V80852 Xanthine oxidase-IN-11 Xanthine oxidase-IN-11 (XO8 analog) is a xanthine oxidase (XO) inhibitor.
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