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Tyrosinase

Tyrosinase

Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases.Tyrosinases are the mammalian enzymes that initiate the production of melanin, the pigment that gives skin and hair their color, as well as the browning of fruits and vegetables after cell damage.

Tyrosinases are involved in pigmentation, wound healing, radiation protection, and the initial immune response. They are present in a variety of prokaryotes in addition to plants, fungi, arthropods, and mammals. The hydroxylation of monophenols and the oxidation of diphenols by tyrosinases results in quinones, which spontaneously polymerize to form melanin. Tyrosinases are crucial for wound healing and basic immune responses in plants, sponges, and a variety of invertebrates; they also aid in sclerotization in arthropods; and they shield DNA from UV ray damage in bacteria.

Tyrosinase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-2-Fluorodeoxyarbutin V120370 (+)-2-Fluorodeoxyarbutin 1446243-88-4 (+)-2-Fluorodeoxyarbutin is a fluorinated derivative of deoxyarbutin and a tyrosinase inhibitor.
(-)-2-Fluorodeoxyarbutin V119576 (-)-2-Fluorodeoxyarbutin 1446243-84-0 (-)-2-Fluorodeoxyarbutin is a fluorinated derivative of deoxyarbutin and a tyrosinase inhibitor.
(-)-Taxifolin ((-)-Dihydroquercetin; (-)-Dihydroquercetin) V71954 (-)-Taxifolin ((-)-Dihydroquercetin; (-)-Dihydroquercetin) 111003-33-9 (-)-Taxifolin is the less active isomer of Taxifolin.
(E)-2-Methoxycinnamaldehyde V121730 (E)-2-Methoxycinnamaldehyde 60125-24-8 (E)-2-Methoxycinnamaldehyde is a tyrosinase inhibitor with an IC50 value of 0.42 mM against mushroom tyrosinase.
(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) V84431 (±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3)
2-Ketoglutaric acid potassium V87754 2-Ketoglutaric acid potassium 997-43-3 2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle.
2-Methoxycinnamic acid V71939 2-Methoxycinnamic acid 6099-03-2 2-Methoxycinnamic acid is a noncompetitive tyrosinase inhibitor.
3-Feruloyl-4',6'-diacetyl sucrose V125376 3-Feruloyl-4',6'-diacetyl sucrose 1823192-28-4 3-Feruloyl-4',6'-diacetyl sucrose is a feruloyl sucrose ester found in the roots of rice (Oryza sativa).
3-O-Ethyl-L-ascorbic acid (vitamin C ethyl ether) V71935 3-O-Ethyl-L-ascorbic acid (vitamin C ethyl ether) 86404-04-8 3-O-Ethyl-L-ascorbic acid, a stable vitamin C analogue, is a cosmetic tyrosinase inhibitor (antagonist) with whitening ability.
4-Ethylresorcinol V71962 4-Ethylresorcinol 2896-60-8 4-Ethylresorcinol is an analogue of resorcinol that serves as a substrate for tyrosinase.
4-Isopropylcatechol V103255 4-Isopropylcatechol 2138-43-4 4-Isopropylcatechol is a potent and irreversible skin depigmenting agent.
4-Prenyloxyresveratrol V93017 4-Prenyloxyresveratrol 69065-16-3 4-Prenyloxy-resveratrol is an oxidized resveratrol derivative with potent tyrosinase inhibitory activity with IC50 of 0.9 μM.
5-epi-Arvestonate A V51532 5-epi-Arvestonate A 2767066-84-0 5-epi-Arvestonate A is a sesquiterpenoid extracted from Seriphidium transiliense.
5-Feruloylquinic acid V71937 5-Feruloylquinic acid 40242-06-6 5-Feruloylquinic acid (5-FQA) has antioxidant and tyrosinase inhibitory activities.
5-Methylresorcinol monohydrate V87747 5-Methylresorcinol monohydrate 6153-39-5 5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor.
6-Hydroxykaempferol V71945 6-Hydroxykaempferol 4324-55-4 6-Hydroxykaempferol, a flavonoid, is a competitive tyrosinase inhibitor (antagonist) with IC50 of 124 μM.
7-Methoxy obtusifolin V71946 7-Methoxy obtusifolin 1820806-09-4 7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor (antagonist) with IC50 of 7.0 μM.
[8]-Dehydrogingerdione V122406 [8]-Dehydrogingerdione 77334-08-8 [8]-Dehydrogingerdione is a hydroxyphenyl ketone.
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 V71949 Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 82188-67-8 Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanogen, a hormone that stimulates melanocytes.
Ailancoumarin E V87746 Ailancoumarin E Ailancoumarin E (Compound 5) is a derivative of Coumarin.
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