Thrombin is a Na+-activated, serine protease that is activated by activated Factor X's enzymatic cleavage of two sites on prothrombin. Two allosteric forms of thrombin, slow (S) and fast (F), are focused on procoagulant and anticoagulant activities, respectively.
By activating platelets, thrombin is the primary effector protease in primary hemostasis and is essential for secondary hemostasis. In addition to its well-known roles in hemostasis, thrombin also contributes to a number of biological and pathophysiologic processes that are not hemostatic, most of which are mediated by the activation of protease-activated receptors (PARs). Thrombin cleaves PAR-1, PAR-3, and PAR-4 whereas trypsin cleaves PAR-2. Additionally, thrombin is essential for the migration and metastasis of human cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V111537 | (21R)-Argatroban | 121785-71-5 | (21R)-Agatroban is a diastereomer of agatroban. |
|
V121344 | (21S)-Argatroban | 121785-72-6 | (21S)-Argatroban is an isomer of argatroban and is a thrombin inhibitor. |
|
V110960 | (2S,4S)-Argatroban | 189264-03-7 | (2S,4S)-Argatroban ((2S,4S)-MD-805) (compound 1c) is a human thrombin inhibitor with a Ki value of 280 μM. |
|
V119710 | 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol | 127994-00-7 | 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol (compound 2e) is a diacylglycerol derivative that can be isolated from the fungus *Stereum hirsutum*. |
|
V71925 | 15,16-Dihydrotanshindiol C (15,16-Dihydrotanshindiol C) | 891854-96-9 | 15,16-Dihydrotanshindiol C is a diterpenoid and a potent thrombin inhibitor. |
|
V126531 | 5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione | 5453-51-0 | 5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione is an inhibitor of dengue virus NS2B-NS3 protease and thrombin. |
|
V128429 | Ainsliaeasin C | 1714097-11-6 | Ainsliaeasin C is a 7-hydroxycoumarin derivative, an oral active anticoagulant extracted from Ainsliaea fragrans. |
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V129144 | Antiplatelet agent 3 | 1623073-71-1 | Antiplatelet agent 3 is a compound with antiplatelet aggregation activity. |
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V94287 | Atecegatran TFA | 433937-75-8 | Artigatran TFA (AR-H067637 TFA) is an anticoagulant with selective direct thrombin inhibitory activity. |
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V71920 | BAY 1217224 | 1639886-32-0 | BAY 1217224 is a neutral non-precursor inhibitor of Thrombin with good oral pharmacokinetics. |
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V129980 | Befovacimab | 2156634-62-5 | Befovacimab is a fully human monoclonal IgG2 antibody that can bind to tissue factor pathway inhibitors (TFPIs). |
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V130275 | Biotinylated-recombinant human thrombin | Biotin-labeled recombinant human thrombin (EC 3.4.21.5) can perform on-column cleavage of fusion proteins with thrombin cleavage sites. | |
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V114261 | Corthrombin | 166247-65-0 | Corthrombin (CVS 995) is a potent α-ketoamide thrombin inhibitor with a Ki value of 1 pM. |
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V114888 | CVS-1123 | 151275-19-3 | CVS-1123 is an orally effective direct thrombin inhibitor. |
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V132678 | Cy3 labled Fitusiran sodium | Cy3-labeled Fitusiran sodium is a type of Fitusiran sodium labeled with Cy3. | |
|
V133161 | Dabigatran acyl-β-D-glucuronide | 1015167-40-4 | Dabigatran acyl-β-D-glucuronide is the active metabolite of the thrombin inhibitor dabigatran. |
|
V71924 | Dabigatran-13C6 (BIBR 953-13C6; BIBR 953ZW-13C6) | 1210608-88-0 | Dabigatran-13C6 is 13C (carbon 13)-labeled Dabigatran. |
|
V71927 | Dabigatran-d3 (BIBR 953-d3; BIBR 953ZW-d3) | 1246817-44-6 | Dabigatran-d3 is the deuterium labelled form of Dabigatran. |
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V77109 | Dabigatran-d4 hydrochloride (Dabigatran D4 hydrochloride; BIBR-953-d4 hydrochloride) | Dabigatran-d4 ( HCl) is the deuterated form of Dabigatran. | |
|
V85751 | Dermatan sulphate sodium (Chondroitin B sulfate) | 54328-33-5 |
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