Serine (Ser) proteases are enzymes that catalyze the hydrolysis of specific peptide bonds in their substrates, and one of the amino acids in the enzyme's active site is always a serine. The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71858 | Phe-Pro-Ala-pNA | 201738-99-0 | Phe-Pro-Ala-pNA is the chromogenic substrate of tripeptidyl peptidase. |
|
V73395 | PKSI-527 | 128837-71-8 | PKSI-527 is a novel, selective plasma kallikrein inhibitor. |
|
V71873 | Plasma kallikrein-IN-1 | 2691030-28-9 | Plasma kallikrein-IN-1 is a PKK inhibitor (antagonist) with IC50 of 0.5 nM. |
|
V71871 | Plasma kallikrein-IN-4 | 1357954-34-7 | Plasma kallikrein-IN-4 (Example 153) is an inhibitor (blocker/antagonist) of plasma kallikrein, with IC50 of 0.016 μM for human plasmKinin. |
|
V71860 | PPACK II diTFA | 649748-23-2 | PPACK II diTFA is an irreversible and specific inhibitor of glandular and plasma kallikreins. |
|
V71882 | PPACKII | 74392-49-7 | PPACK II is an irreversible, specific inhibitor of glandular and plasma kallikreins. |
|
V73396 | Proteinase K (protease K; Protease K) | 39450-01-6 | Proteinase K (Protease K) is a non-specific serine protease used for protein digestion. |
|
V71897 | Ralpancizumab | 1407495-04-8 | Ralpancizumab is a PCSK9 selective inhibitor (antagonist) with potential application in hemorrhagic stroke. |
|
V71870 | Recaticimab (SHR-1209) | 2361290-85-7 | Recaticimab (SHR-1209) is a humanized monoclonal antibody (mAb) that can inhibit PCSK9. |
|
V71898 | Recombinant enterokinase (rEK) | 9014-74-8 | Recombinant enterokinase (rEK) is a serine protease that functions as a physiological activator of trypsinogen. |
|
V71885 | Recombinant Kex2 protease | 99676-46-7 | Recombinant Kex2 protease is a membrane-bound, Ca2+-dependent serine protease. |
|
V81280 | Recombinant Proteinase K | Recombinant Proteinase K is a serine protease that can cleave the carboxyl-terminal peptide bonds of aliphatic and aromatic amino acid (AA)s. | |
|
V73405 | SBC-115337 | 423148-46-3 | SBC-115337 is a potent benzofuran compound and PCSK9 inhibitor (antagonist) with IC50 of 0.5 μM. |
|
V73404 | Sebetralstat (KVD900) | 1933514-13-6 | Sebetralstat (KVD900) is a plasmKininase inhibitor (WO2016083820). |
|
V71914 | SPC4061 | 1018108-22-9 | SPC4061 is an antisense nucleotide and a potent PCSK9 inhibitor. |
|
|
V81424 | SPC4061 sodium | SPC4061 sodium is an antisense nucleotide and a potent PCSK9 inhibitor. | |
|
V71905 | Suc-AAPA-pNA | 72682-69-0 | Suc-AAPA-pNA is a substrate of chymotrypsin Aα. |
|
V71913 | Tafolecimab (IBI-306) | 2225109-03-3 | Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody (mAb) that specifically binds to PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the low-density lipoprotein receptor, thereby enhancing The clearance of LDL-C leads to a decrease in LDL-C levels. |
|
V71877 | TAO Kinase inhibitor 2 | 850467-77-5 | TAO Kinase inhibitor 2 (Example 49) is a TAO kinase inhibitor (IC50=50-500 nM). |
|
V51697 | Tilpisertib (GS-4875) | 2065153-41-3 | Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689). |
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