Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and a member of the orphan nuclear receptor family. Three members of the ROR subfamily—ROR (NR1F1), ROR (NR1F2), and ROR (NR1F3)—are ligand-dependent transcription factors.
According to reports, RORs play a role in the development of secondary lymphoid tissues, autoimmune and inflammatory diseases, the circadian rhythm, and metabolism homeostasis. They are also thought to activate transcription through ligand-dependent interactions with co-regulators.
Important immune system regulators include ROR and ROR. These elements are necessary for the growth and differentiation of Th17 cells. Inflammation and autoimmune disease are facilitated by ROR, which is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and T cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67800 | RORγt Inverse agonist 3 | 2364429-77-4 | RORγt Inverse agonist 3 is a selective, orally bioactive inverse agonist of the retinoic acid receptor-related orphan receptor RORγ. |
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V81323 | RORγt inverse agonist 31 | RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist/activator with IC50 of 0.428 μM. | |
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V67796 | RORγt Inverse agonist 6 | 1887161-80-9 | RORγt Inverse agonist 6 (compound 43) is an inverse agonist of RORγt and may be utilized in the study of Th17-driven autoimmune diseases. |
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V67811 | SHR168442 | 2382961-86-4 | SHR168442 is a modulator of RORγ with IC50 of 0.035 μM. |
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V33196 | SR1001 | 1335106-03-0 | SR1001 (SR-1001) is a novel, potent and selective antagonist/inhibitor/inverse agonist of the nuclear retinoic acid receptor-related orphan receptorsRORα and RORγ with immunomodulatory effects. |
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V7133 | TMP778 | 1422053-04-0 | TMP778 (TMP-778; TMP 778) is a novel and potent RORγt inverse agonist with potential anti-inflammatory activity. |
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V67808 | Vimirogant hydrochloride (VTP-43742 hydrochloride) | 1802678-42-7 | Vimirogant (VTP-43742) HCl is a selective, orally bioactive RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). |
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V73452 | Zilovertamab (UC-961; Cirmtuzumab) | Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody (mAb) that blocks Wnt5a-induced ROR1 signaling pathway. |
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