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MMP

MMP

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.

MMP related products

Structure Cat No. Product Name CAS No. Product Description
(R)-ND-336 V73230 (R)-ND-336 2252493-33-5 (R)-ND-336 is a potent and specific MMP-9 inhibitor (antagonist) with Ki of 19 nM.
(S,S)-TAPI-0 V89019 (S,S)-TAPI-0 143457-40-3 (S,S)-TAPI-0 is a matrix metalloproteinase (MMP) inhibitor that inhibits the growth of Chlamydia trachomatis by inhibiting PDF enzyme activity.
14-3-3-IN-2 V117198 14-3-3-IN-2 919751-10-3 14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC50 value of 15 nM.
3,3′-Bisdemethylpinoresinol V73262 3,3′-Bisdemethylpinoresinol 340167-81-9 3,3′-Bisdemethylpinoresinol, lignin, is a naturally occurring compound with MMP-1 inhibitory activity on UVA-irradiated human dermal fibroblasts.
3-Aminobenzene-1,2-diol V105509 3-Aminobenzene-1,2-diol 20734-66-1 3-Aminobenzene-1,2-diol (Compound C8) is a matrix metalloproteinase (MMP) inhibitor with IC50 values of 20, 26, 16, and 16.3 μM for MMP-2, MMP-8, MMP-9, and MMP-14, respectively.
3-Hydroxy-2-pyrone V111850 3-Hydroxy-2-pyrone 496-64-0 3-Hydroxy-2-pyranone (compound 12d) is a metalloenzyme inhibitor.
4-Epianhydrochlortetracycline hydrochloride V102751 4-Epianhydrochlortetracycline hydrochloride 158018-53-2 4-epitope chlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), especially gelatinase B (EC 3.4.24.35), with an inhibition rate of 100% at 500μg/mL, 70% at 125μg/mL, and 40% at 31μg/mL.
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt V73256 Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt 98992-65-5 Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate and may be utilized to detect MMP12 enzyme activity.
ADAM17-IN-1 V118457 ADAM17-IN-1 1802395-34-1 ADAM17-IN-1 is a selective ADAM17 inhibitor.
ADAM8-IN-1 V73254 ADAM8-IN-1 2758892-64-5 ADAM8-IN-1 is a potent ADAM8 inhibitor (antagonist) with IC50 of 73 nM.
Aderamastat (FP-025) V73245 Aderamastat (FP-025) 877176-23-3 Aderamastat (FP-025) is an orally bioactive matrix metalloproteinase 12 (MMP-12) inhibitor.
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) V87609 Anti-Human/Mouse denatured collagen type-I Antibody (XL313) Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse derived IgG1, κ antibody inhibitor against human or mouse denatured collagen type-I.
ASPH-IN-1 V111197 ASPH-IN-1 2477878-52-5 ASPH-IN-1 (compound 14c) is an orally effective ASPH inhibitor.
Berkeleyamide B V118664 Berkeleyamide B 1019854-22-8 Berkeleyamide B is a dual inhibitor of metalloproteinase-3 (MMP-3) and caspase-1.
Berkeleyamide C V118461 Berkeleyamide C 1019854-23-9 Berkeleyamide C is a selective inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1.
BPHA V73222 BPHA 193807-60-2 BPHA is a potent orally bioactive inhibitor of MMP-2, MMP-9 and MMP-14 with IC50 of 12 nM, 16 nM and 17 nM respectively.
C-telopeptide TFA V119967 C-telopeptide TFA C-terminal peptide TFA is a cross-linked peptide of type I collagen, released during bone resorption, and is associated with bone mineral density (BMD).
CGS 27023A V89020 CGS 27023A 169799-04-6 CGS 27023A is a non-peptide, orally active MMP inhibitor with Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 and MMP-9, respectively.
CGS 27023A free base V115421 CGS 27023A free base 161314-70-1 CGS 27023A free base is a non-peptide, orally effective MMP inhibitor with Ki values of 43, 33, 20, and 8 nM for MMP-3, MMP-1, MMP-2, and MMP-9, respectively.
cis-ACCP V73233 cis-ACCP 777075-44-2 cis-ACCP is an antimetastatic matrix metalloproteinase 2 (MMP-2) selective inhibitor (antagonist) with oral activity.
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