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Liposome

Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. The hydrophobic tails self-orient in aqueous environments, forming a spherical structure with an aqueous core and a lipophilic bilayer membrane surrounding it. Liposomes can be made to be both biocompatible and biodegradable (for instance, at a particular pH and temperature) by changing the lipid composition. Additionally, there are a number of modifications that can be made to liposomes to increase their effectiveness as drug delivery vehicles.

Liposome related products

Structure Cat No. Product Name CAS No. Product Description
((1-Hydroxybutan-2-yl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate) V121111 ((1-Hydroxybutan-2-yl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate) 2036273-20-6 ((1-Hydroxybutan-2-yl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) is an ionizable cationic lipid (pKa = 4.67) and a derivative of ALC-0315.
(2S)-3-Keto sphinganine (d6:0) (hydrochloride) V96803 (2S)-3-Keto sphinganine (d6:0) (hydrochloride) 1314999-30-8 (2S)-3-Ketosphingosine (d6:0) ((2S)-3-keto-C6-dihydrosphingosine) hydrochloride is a lipid compound that can be used to prepare liposomes.
(6Z,16Z)-12-((Z)-Dec-4-enyl)docosa-6,16-dien-11-yl 5-(dimethylamino)pentanoate V60066 (6Z,16Z)-12-((Z)-Dec-4-enyl)docosa-6,16-dien-11-yl 5-(dimethylamino)pentanoate 1450888-71-7 Genevant CL1 is an ionizable cationic lipid (lipid 10, pKa=6.3) that can be used for mRNA lipid nanoparticle (LNP) vaccine delivery [1][2].
(R)-C12-200 V121907 (R)-C12-200 1226777-45-2 (R)-C12-200 is the (R)-isomer of C12-200, which is an ionizable cationic lipid and an auxiliary lipid.
(R)-Chol-TPP V77379 (R)-Chol-TPP (R)-Chol-TPP is a mitochondria-targeted liposomal ligand for pH-redox reactions.
(R)-DPPE-mPEG2000 V121922 (R)-DPPE-mPEG2000 205494-72-0 (R)-DPPE-mPEG2000 is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
(Rac)-SOPC V118739 (Rac)-SOPC 6753-56-6 (Rac)-SOPC ((Rac)-PC(18:0/18:1)) ((Rac)-2-oleoyl-1-stearoyl-sn-glycerol-3-phosphocholine) is a racemic mixture of SOPC.
(S)-DSPC V119882 (S)-DSPC 66701-63-1 (S)-DSPC ((S)-1,2-distearyl-sn-glycerol-3-PC) is the (S)-enantiomer of DSPC.
(S)-O12-D3-I3 V111071 (S)-O12-D3-I3 3041009-08-6 (S)-O12-D3-I3 is an ionizable cationic lipid (pKa = 6.39).
(S,S)-DPPG V122266 (S,S)-DPPG (S,S)-DPPG is an enantiomer of L-DPPG.
(Z)-KC02 V73412 (Z)-KC02 1646795-60-9 (Z)-KC02 is an inhibitor (blocker/antagonist) of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS.
1,2(R)-Dioleyloxy-3-dimethylamino-propane V102567 1,2(R)-Dioleyloxy-3-dimethylamino-propane 666234-78-2 1,2(R)-Dioleyl-3-dimethylaminopropane ((R)-DODMA) is an ionizable cationic lipid and an isomer of DODMA.
1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine V90381 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 36314-47-3 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine (16:0 Diether PC) is a phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions and is commonly used to prepare liposomes and artificial membranes to study membrane dynamics.
1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) V84244 1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) 5634-86-6
1,2-Diarachidoyl-sn-glycero-3-phosphocholine V90376 1,2-Diarachidoyl-sn-glycero-3-phosphocholine 61596-53-0 1,2-Diarachidoyl-sn-glycero-3-phosphocholine (1,2-DAPC) is a phospholipid with saturated long-chain (20:0) arachidonic acid inserted at the sn-1 and sn-2 positions.
1,2-Dibehenoyl-sn-glycero-3-phosphocholine V87538 1,2-Dibehenoyl-sn-glycero-3-phosphocholine 17688-29-8 1,2-Dibehenoyl-sn-glycero-3-phosphocholine (DBPC) is a phospholipid found in cell membranes.
1,2-Didecanoyl PC V90347 1,2-Didecanoyl PC 3436-44-0 1,2-Didecanoyl PC (1,2-Didecanoyl-sn-glycero-3-phosphocholine) is a phosphocholine that can be introduced into single-chain mean field theory as a coarse-grained model of saturated phospholipids.
1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine V90352 1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine 253685-27-7 1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine is a phospholipid that shows very promising P-gp inhibitory effects at 0.3 mM concentration.
1,2-Dierucoyl-sn-glycero-3-PE V122657 1,2-Dierucoyl-sn-glycero-3-PE 904304-57-0 1,2-Dierucoyl-sn-glycero-3-PE is a phospholipid containing erucic acid.
1,2-Dilauroyl-sn-glycero-3-phosphate sodium V90380 1,2-Dilauroyl-sn-glycero-3-phosphate sodium 108321-06-8 1,2-Dilauroyl-sn-glycero-3-phosphate (1,2-DLPA) sodium is a phospholipid with medium-chain (12:0) lauric acid inserted at the sn-1 and sn-2 positions and can be used for the preparation of liposomes.
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