Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme which catalyzes the initial and rate limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed in professional APCs, epithelial cells, vascular endothelium and tumor cellsIDO is a crucial enzyme in the initiation and spread of cancer. It encourages tumor angiogenesis, immune tolerance to tumor antigens in stromal and immune cells, suppression of T and NK cells, production and activation of T regulatory cells (Tregs), and myeloid-derived suppressor cells. It also supports inflammation in the tumor microenvironment.According to reports, functionally active IDO protein is expressed in a wide range of human hematologic malignancies, including breast cancer, colorectal cancer, endometrial cancer, gastric cancer, glioblastoma, gynecological cancers, head and neck cancers, non-small cell lung cancer (NSCLC), melanoma, and pancreatic cancer. The IDO pathway is emerging as a crucial method for the treatment of cancer as an immune checkpoint pathway.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51703 | IDO1-IN-7 | 2351199-98-7 | IDO1-IN-7 is a specific IDO1 with IC50 of 6.1 nM for IDO1 in cells. |
|
V51702 | IDO1/2-IN-1 | 2310286-45-2 | IDO1/2-IN-1 is the first effective dual reduction of IDO1/IDO2, with IC50 of 28 nM and 144 nM for IDO1 and IDO2, respectively. |
|
V73186 | IDO1/TDO-IN-6 | 2948772-71-0 | IDO1/TDO-IN-6 (compound 11) is a dual (bifunctional) inhibitor of IDO1/TDO with IC50 of 2.25 and 2.89 μM, respectively. |
|
V51704 | Imsamotide (IDO194-214) | 2130836-27-8 | Ixamotide (IDO194-214) is an ethanolamine 2,3-dioxygenase (IDO) peptide with the sequence DTLLKALLEIASCLEKALQVF. |
|
V51725 | Kushenol E | 99119-72-9 | Kushenol E is a flavonoid extracted from Sophora flavescens. |
|
V51715 | NUCC-0223619 | 1923835-78-2 | NUCC-0223619 is an IDO1 inhibitor and induces IDO protein degradation. |
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