HMGCR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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HMGCR

HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate.Eukaryotes and prokaryotes both contain HMGCR. Two classes of HMG-CoA reductase have been identified through phylogenetic analysis: Class I enzymes found in some eukaryotes and archaea and Class II enzymes found in some eubacteria and other archaea.

The enzyme HMGCR is known to catalyze an early reaction specific to isoprenoid biosynthesis in both eukaryotes and archaebacteria. Drugs used to lower serum cholesterol levels frequently target the HMG-CoA reductase reaction because it is rate-limiting for the biosynthesis of cholesterol in humans.

HMGCR related products

Cat No.	Product Name	CAS No.	Product Description
V105922	(Z)-Ganoderenic acid K	1910062-54-2	(Z)-Ganoderenic acid K is a triterpene acid that can be isolated from the basidiocarp of Ganoderma lucidum.
V107128	24,25-Epoxycholesterol	72542-49-5	24,25-Epoxycholesterol is an oxysterol agonist of liver X receptors and inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) in hepatocytes.
V93945	Atorvastatin strontium	1072903-92-4	Strontium atorvastatin is a cholesterol-lowering drug with activity in improving cardiovascular disease-related events.
V74034	Bemfivastatin hemicalcium (PPD 10558 hemicalcium)	805241-64-9	Bemfivastatin (PPD 10558) hemicalcium is an orally bioactive lipid-lowering agent and HMG-CoA reductase inhibitor.
V109024	BMS-180431 sodium	131177-45-2	BMS-180431 sodium is an HMG-CoA reductase inhibitor (IC50: 43 nM).
V112700	Colestolone	50673-97-7	Cholestone is a 15-ketosterol compound and an HMG-CoA reductase inhibitor.
V103146	Fluvastatin lactone	94061-83-3	Fluvastatin lactone, the lactone form of fluvastatin, induces myotoxicity in human skeletal muscle cells.
V74033	Ganoderenic acid K	942950-94-9	Ganoderenic acid K is a naturally occurring compound extracted from the fruiting bodies of Ganoderma lucidum.
V94527	Ganoderic acid SZ	865543-37-9	Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity.
V114372	Glenvastatin	122254-45-9	Glenvastatin (HR 780) is an orally effective 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor.
V112208	GR 92549	144501-27-9	GR 92549 is a potent, orally effective competitive HMG-CoA reductase inhibitor that can be used as a cholesterol-lowering drug.
V78583	HMG-CoA Reductase-IN-1		HMG-CoA Reductase-IN-1 is an HMG-CoA reductase inhibitor.
V74036	L-157012	114801-28-4	L-157012 is an HMG-CoA reductase (HMGCR) inhibitor.
V116128	PF-3052334	887702-61-6	PF-3052334 is an orally effective liver-selective HMG-CoA reductase inhibitor with an IC50 value of 1.9 nM.
V117761	Phenicin	128-68-7	Phoenicine is a microbial metabolite and an irreversible inhibitor of HMG-CoA reductase (HMGCR).
V114338	Pitavastatin magnesium	956116-90-8	Pitavastatin magnesium is an orally effective HMG-CoA reductase inhibitor.
V74035	Pravastatin lactone (pravastatin ester)	85956-22-5	Pravastatin lactone is a potent HMG-CoA inhibitor.
V109105	PROTAC HMGCR Degrader-1	2715104-45-1	PROTAC HMGCR Degrader-1 is an orally effective HMGCR PROTAC degrader with an IC50 of 1.32 μM, and is also a lactone prodrug derivative of PROTAC HMGCR Degrader-2.
V114836	SQ-33600	133983-25-2	SQ-33600 is an HMG-CoA reductase inhibitor with cholesterol-lowering activity.
V4949	SR12813	126411-39-0	SR12813,a 1,1-bisphosphonate ester, is a novel and potent pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.