Epoxide hydrolases (EH) are a component of every living thing. A 120 kDa dimer of two identical, 62.5 kDa monomers arranged in an anti-parallel manner makes up the mammalian soluble epoxide hydrolase (sEH). The liver, kidneys, brain, endothelium, and to a lesser extent other tissues, express it most prominently. Many disease states have significant components of inflammation and pain. Blood pressure, inflammation, and pain are all decreased by mammalian sEH inhibition. The down-regulation of COX2 transcription caused by NF-B, which results in less production of pro-inflammatory prostaglandins like PGE2 and PGD2, is a contributing factor in the anti-inflammatory activities of sEH inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121740 | (E)-3-Feruloylquinic acid | 87099-72-7 | (E)-3-Feruloylquinic acid is a chlorogenic acid. |
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V51413 | (Rac)-EC5026 ((Rac)-BPN-19186) | 1809885-55-9 | (Rac)-EC5026 ((Rac)-BPN-19186) is an example of a potent soluble epoxy hydrolase (sEH) with a Ki of 0.06 nM. |
|
V99807 | (±)10(11)-EpDPA | 895127-65-8 | (±)10(11)-EpDPA is a metabolite of docosahexaenoic acid epoxidase and can serve as a substrate for soluble epoxide hydrolase (sEH) with a Km value of 5.1 µM for human sEH. |
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V84657 | 10,11-EDT | 2763501-00-2 | |
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V112302 | 4H-Tomentosin | 68776-19-2 | 4H-Tomentosin is a mixed competitive inhibitor of soluble epoxide hydrolase (sEH) with an IC50 of 6.84 μM and a Ki of 7.02 μM. |
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V11535 | AR-9281 | 913548-29-5 | AR-9281 is a novel and potent inhibitor of soluble epoxide hydrolase (s-EH) that can be potentially used for the treatment of hypertension and type 2 diabetes. |
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V129344 | Arabinothalictoside | 153287-94-6 | Arabinoglucosinolates are found in custard apple (A. squamosa L.). |
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V116553 | BRP-821 | BRP-821 is a soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 0.4 nM. | |
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V94884 | DJ-53 | DJ-53 (Compound 68) is an orally active phenylquinoline-based soluble epoxide hydrolase inhibitor. | |
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V133953 | DJ-89 | DJ-89 is a potent soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 0.51 nM. | |
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V37609 | EC-5026 (BPN-19186) | 1809885-32-2 | EC5026 (BPN19186) is a novel, first-in-class, potent and orally bioabailable inhibitor of soluble Epoxide Hydrolase (sEH). |
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V87415 | Epoxykynin | 640263-95-2 | Epoxykynin is a potent epoxide hydrolase (sEH) inhibitor. |
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V84770 | FZQ-21 | ||
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V2720 | GSK2256294A | 1142090-23-0 | GSK2256294A (also known as GSK-2256294) is a novel, potent, selective inhibitor of recombinant human, rat and mouse sEH (Soluble epoxide hydrolase) (IC50 = 27 pM) with the potential to be used for endothelial dysfunction or abnormal tissue repair, such as diabetes, wound healing or COPD. |
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V104764 | Hydroxytyrosol 1-O-glucoside | 76873-99-9 | Hydroxytyrosol 1-O-glucoside (Dopaol glucoside) is a glycoside with antioxidant activity. |
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V137772 | Ibuprofenamide | 59512-17-3 | Ibuprofenamide is a potent inhibitor of microsomal epoxide hydrolase (mEH) with an IC50 value of 96 μM. |
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V93293 | LQ-38 | LQ-38 is an orally available soluble epoxide hydrolase (sEH) inhibitor with IC50 of 5.2 nM. | |
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V140189 | Moracin M 3’-O-β-glucopyranoside | Moroside M 3'-O-β-glucopyranoside is present in mulberry bark. | |
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V143395 | PROTAC sEH degrader-2 | PROTAC sEH degrader-2 is a PROTAC targeted degrader that degrades soluble epoxide hydrolase (sEH). The pIC50 values of its catalytic domain are 8.37 (human sEH-H) and 7.12 (mouse sEH-H). | |
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V120206 | PROTAC sEH-degrader-3 | 3093413-94-3 | PROTAC sEH degrader-3 (compound 1a) is a PROTAC-targeting sEH degrader that selectively degrades sEH in the cytoplasm without affecting sEH in the peroxisome. |
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