A protein modifier called ubiquitin (UB) controls a variety of vital cellular functions. The E1 enzyme activates UB's C-terminal carboxylate to start the process of UB's transfer through the E1-E2-E3 cascade onto target proteins. The ubiquitin is attached to the E1 enzyme by a thioester bond during an ATP-dependent reaction, and this enzyme serves as the activating enzyme. The ubiquitin is transferred from the E1 enzyme to the conjugating E2 enzyme. The E3 enzyme, also known as the ubiquitin ligase, catalyzes the transfer of ubiquitin to the target protein (also known as the substrate) by forming an isopeptide bond.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V80899 | Navtemadlin-d7 (AMG 232-d7; KRT-232-d7) | Navtemadlin-d7 is the deuterated form of Navtemadlin. | |
|
V73085 | RB-3 | 2396639-11-3 | RB-3 is an inhibitor (blocker/antagonist) of PRC1 and binds to RING1B-BMI1f with Kd of 2.8 μM. |
|
V73091 | RNF5 inhibitor inh-02 | 324579-65-9 | RNF5 inhibitor inh-02 is a potent inhibitor of the E3 ubiquitin ligase RNF5/RMA1. |
|
V73095 | Rugonersen (RG6091; RO7248824) | 2591587-57-2 | Rugonersen (RG6091; RO7248824) is a locked nucleic acid (LNA)-modified antisense oligonucleotide (ASO) that reduces ubiquitin protein ligase E3A (UBE3A) silencing. |
|
V73098 | SCFSkp2-IN-2 | 1375060-02-8 | SCFSkp2-IN-2 (Compound AAA-237) is a Skp2 inhibitor (antagonist) with a KD of 28.77 μM. |
|
V73093 | SENP1-IN-1 | 2416910-69-3 | SENP1-IN-1 is an inhibitor (blocker/antagonist) of the specific de-SUMOylation protease SENP1. |
|
V73111 | SENP1-IN-2 | 2416910-70-6 | SENP1-IN-2 is an inhibitor (blocker/antagonist) of the specific de-SUMOylation protease SENP1. |
|
V73100 | SENP1-IN-3 | 2416910-59-1 | SENP1-IN-3 is an inhibitor (blocker/antagonist) of the specific de-SUMOylation protease SENP1. |
|
V73108 | SENP1-IN-4 | 2416910-64-8 | SENP1-IN-4 is an inhibitor (blocker/antagonist) of the specific de-SUMOylation protease SENP1. |
|
V73084 | Skp2 inhibitor 2 | 2760612-77-7 | Skp2 inhibitor 2 (14f) is an inhibitor (blocker/antagonist) of the F-box protein S-phase kinase-related protein 2 (Skp2) with IC50 of 10.2 μM (Skp2-Cks1). |
|
V73116 | Smurf1-IN-1 | 1824708-03-3 | SMURF1-IN-1 is an orally bioactive and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with IC50 of 92 nM. |
|
V73096 | TRAF6 peptide | 852805-92-6 | TRAF6 peptide is a specific inhibitor of TRAF6-p62 interaction. |
|
V76400 | TRAF6 peptide TFA | TRAF6 peptide TFA is a specific inhibitor of TRAF6-p62 interaction. | |
|
V73087 | UBA5-IN-1 | 1831169-11-9 | UBA5-IN-1 (compound 8.5) is a selective inhibitor of UBA5 with IC50 of 4.0 μM. |
|
V73089 | UBE2T/FANCL-IN-1 | 1359415-02-3 | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitination and sensitizes cells to the DNA cross-linker carboplatin. |
|
V81661 | Ubiquitination-IN-2 | Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein-protein interaction (PPI). | |
|
V73115 | UC-764864 | 278806-03-4 | UC-764864 is a UBE2N inhibitor. |
|
V51002 | WAY-608248 | 308297-79-2 | Skp2 inhibitor |
|
V73092 | WSB1 Degrader 1 | 2306039-66-5 | WSB1 Degrader 1 is a potent orally bioactive WSB1 (WD repeat and SOCS box-containing 1) degrader. |
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