Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid.Ceramidases, which play a crucial role in the pathophysiology of diseases with altered lipid homeostasis like Alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular conditions, regulate the breakdown of ceramides. According to the pH ideal for their catalytic activity, ceramidases are divided into the acid, neutral, and alkaline ceramidase subtypes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73040 | Cysteine Protease inhibitor hydrochloride (cysteine protease inhibitor (hydrochloride)) | 2197053-49-7 | Cysteine Protease inhibitor HCl is a cysteine protease inhibitor. |
|
V73922 | D-erythro-MAPP (De-MAPP) | 143492-38-0 | D-erythro-MAPP (De-MAPP) is an inhibitor (blocker/antagonist) of ceramidase with an in vitro IC50 of 1-5 μM. |
|
V73031 | GSK-2793660 | 1613458-78-8 | GSK-2793660 is an orally bioactive and irreversible inhibitor of cathepsin C (CTSC). |
|
V73043 | H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH | 90331-82-1 | H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble peptide that serves as a substrate for cathepsin D, pepsin, and pepsinogen. |
|
V73036 | Hepcidin-1 (mouse) | 1676104-75-8 | Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. |
|
V73030 | p-Aminophenylmercuric acetate | 6283-24-5 | p-Aminophenylmercuric acetate is an organomercuric matrix metalloproteinase (MMP) activator. |
|
V73054 | Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) | 70195-20-9 | Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) is a competitive inhibitor of Papain with Ki of 9 μM at pH 6.2. |
|
V73048 | RKLLW-NH2 | 289480-71-3 | RKLLW-NH2 is a cathepsin L inhibitor. |
|
V73035 | RO5461111 | 1252637-46-9 | RO5461111 is a specific, orally bioactive Cathepsin S antagonist (IC50= 0.4 nM, human Cathepsin S; 0.5 nM, murine Cathepsin S). |
|
V73041 | Suc-Val-Pro-Phe-pNA | 95192-11-3 | Suc-Val-Pro-Phe-pNA is a substrate for cathepsin G and may be utilized to detect the activity of this enzyme. |
|
V73042 | Z-Arg-Arg-AMC | 88937-61-5 | Z-Arg-Arg-AMC is a selective substrate for cathepsin B. |
|
V73038 | Z-Arg-Arg-AMC hydrochloride | 136132-67-7 | Z-Arg-Arg-AMC HCl is a selective cathepsin B substrate. |
|
V73053 | Z-Arg-Arg-pNA | 122630-71-1 | Z-Arg-Arg-pNA is a substrate for cathepsin B and may be utilized to detect the activity of this enzyme. |
|
V73061 | Z-DEVD-CMK | 250584-13-5 | Z-DEVD-CMK is an irreversible inhibitor of most cathepsins in vitro. |
|
V73067 | Z-FG-NHO-Bz | 118292-22-1 | Z-FG-NHO-Bz is a selective cathepsin inhibitor. |
|
V73066 | Z-FG-NHO-BzOME | 180313-86-4 | Z-FG-NHO-BzOME is a cysteine protease inhibitor that can selectively inhibit cathepsin B, cathepsin L, cathepsin S and papain. |
|
V73029 | Z-FY-CHO (Z-Phe-Tyr-CHO) | 167498-29-5 | Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of cathepsin L (CTSL). |
|
V73057 | Z-Gly-Pro-Arg-AMC hydrochloride | 201928-42-9 | Z-Gly-Pro-Arg-AMC HCl is a fluorescent trypsin and cathepsin K substrate. |
|
V73045 | Z-Leu-Leu-Arg-AMC | 90468-17-0 | Z-Leu-Leu-Arg-AMC is a bioactive peptide substrate of cathepsin S. |
|
V73039 | Z-Leu-Tyr-Chloromethylketone | 56979-35-2 | Z-Leu-Tyr-Chloromethylketone is a calpain |
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