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Aldose Reductase

Aldose Reductase

Aldose reductase is a tiny, cytosolic, monomeric enzyme that is a member of the aldo-keto reductase superfamily. Numerous aromatic and aliphatic carbonyl compounds are reduced by aldose reductase using the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH). It has been linked to the emergence of diabetic and galactosemic complications that affect the kidney, nerves, lens, and retina.

Aldose reductase is a crucial polyol pathway enzyme that, when activated under hyperglycemic conditions, causes the development of chronic diabetic complications. It is also a key factor in the promotion of inflammatory and cytotoxic conditions, even when blood sugar levels are normal. Aldose reductase is a fantastic drug target, and there is a lot of work being done to identify new substances that can inhibit it.

Aldose Reductase related products

Structure Cat No. Product Name CAS No. Product Description
(Rac)-Ganoderic acid C2 V105992 (Rac)-Ganoderic acid C2 98296-48-1 (Rac)-Ganoderic acid C2 is the racemate of Ganoderic acid C2.
3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni V110026 3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni 3α-hydroxysteroid dehydrogenase (produced by Pseudomonas testosteroneae, EC 1.1.1.50) belongs to the oxidoreductase family.
4′-Hydroxyflavone V107035 4′-Hydroxyflavone 4143-63-9 4′-Hydroxyflavone (Compound 50) can inhibit aldose reductase with a log1/IC50 of 4.92.
5-Bromo-3-phenyl salicylic acid V87286 5-Bromo-3-phenyl salicylic acid 99514-99-5 5-Bromo-3-phenyl salicylic acid is a selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with Ki value of 140 nM.
6,7-Dihydroxy-4-coumarinylacetic acid V73734 6,7-Dihydroxy-4-coumarinylacetic acid 88404-14-2 6,7-Dihydroxy-4-coumarinylacetic acid is a potent and specific inhibitor of ALR2.
6-Hydroxyluteolin V73729 6-Hydroxyluteolin 18003-33-3 6-Hydroxyluteolin (Compound 17) is a flavonoid compound.
AKR1B10-IN-1 V73733 AKR1B10-IN-1 2136579-33-2 AKR1B10-IN-1 is a potent inhibitor of AKR1B10 with IC50 of 3.5 nM.
AKR1C2/3-IN-1 V87281 AKR1C2/3-IN-1 AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC50 values of 90 and 50 nM, respectively.
AKR1C3-IN-10 V77870 AKR1C3-IN-10 3028287-43-3 AKR1C3-IN-10 (compound 5r) is a selective AKR1C3 inhibitor (IC50=51 nM).
AKR1C3-IN-11 V83455 AKR1C3-IN-11
AKR1C3-IN-12 V87284 AKR1C3-IN-12 891075-67-5 AKR1C3-IN-12 (compound 2j) is an aldehyde-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 27 nM.
AKR1C3-IN-14 V87283 AKR1C3-IN-14 1057882-82-2 AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling.
AKR1C3-IN-9 V73732 AKR1C3-IN-9 2924824-43-9 AKR1C3-IN-9 is a selective inhibitor of aldehyde-keto reductase 1C3 (AKR1C3) with IC50 of 8.92 nM.
Aldose reductase-IN-7 V87285 Aldose reductase-IN-7 Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase and exhibits potent enzyme inhibitory activity (Ki = 0.186 ± 0.020 μM), which is superior to Epalrestat.
Aldose reductase-IN-9 V118662 Aldose reductase-IN-9 Aldose reductase-IN-9 (compound 8b) is an aldose reductase (ALR2) inhibitor with a Ki value of 3.59 nM.
ALR2-IN-1 V73731 ALR2-IN-1 2799695-54-6 ALR2-IN-1 is a potent and specific inhibitor of ALR2 (IC50=1.42 μM).
ALR2-IN-10 V110970 ALR2-IN-10 135-64-8 ALR2-IN-10 (compound 23) is a weak aldose reductase 2 inhibitor with an inhibition rate of 6% at a concentration of 27 μM.
ALR2-IN-2 V80090 ALR2-IN-2 ALR2-IN-2 is a potent aldose reductase (ALR2) inhibitor, with IC50s of 27 nM and 228 nM for rat ALR2 and ALR1 inhibition, respectively.
ALR2-IN-3 V80087 ALR2-IN-3 ALR2-IN-2 is a potent aldose reductase (ALR2) inhibitor, with IC50s of 22 nM and 116 nM for rat ALR2 and ALR1 inhibition, respectively.
ALR2-IN-5 V99021 ALR2-IN-5 ALR2-IN-5 (Compound 10a) is an inhibitor of ALR2 with IC50 value of 99.29 nM.
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