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NO Synthase

NO Synthase

A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.

NO Synthase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Hannokinol V75149 (+)-Hannokinol 408324-76-5 (+)-Hannokinol can be extracted from the fruits of AMOMUM TSAO-KO (Zingiberaceae).
(+)-Igmesine hydrochloride V121183 (+)-Igmesine hydrochloride (+)-Igmesine hydrochloride is an orally effective selective σ1 receptor ligand with an IC50 of 39 nM.
(+)-Rhododendrol ((S)-(+)-Rhododendrol; (+)-Betuligenol) V84404 (+)-Rhododendrol ((S)-(+)-Rhododendrol; (+)-Betuligenol) 59092-94-3
(-)-10,11-Dihydroxyfarnesol V75146 (-)-10,11-Dihydroxyfarnesol 37133-76-9 (-)-10,11-Dihydroxyfarnesol is a compound extracted from the endophytic fungus Cryptomarasmius aucubae.
(-)-Cryptamide C V121137 (-)-Cryptamide C 1353772-63-0 (-)-Cryptamide C is a trimer of the dopamine enantiomer.
(-)-Sesamin 2,2'-diol V121157 (-)-Sesamin 2,2'-diol 1152441-87-6 (-)-Sesamin 2,2'-diol is a nitric oxide (NO) generation inhibitor with an IC50 value of 310 μM that inhibits lipopolysaccharide (LPS)-induced NO generation.
(2R)-6-Methoxynaringenin V101873 (2R)-6-Methoxynaringenin 1212075-61-0 (2R)-6-methoxynaringenin is the R-form of 6-methoxynaringenin.
(E)-Sinapoyl glucose V111829 (E)-Sinapoyl glucose 78185-48-5 (E)-Sinosinol glucose is an inhibitor of an inflammatory pathway.
(R)-Zevaquenabant V121971 (R)-Zevaquenabant (R)-Zevaquenabant is an enantiomer of Zevaquenabant.
(Rac)-Isogosferol V122021 (Rac)-Isogosferol 152441-79-7 (Rac)-Isogosferol is a furanocoumarin found in the fruit of Cnidium monnieri (L.) Cusson.
(Rac)-Zevaquenabant ((Rac)-MRI-1867) V71565 (Rac)-Zevaquenabant ((Rac)-MRI-1867) 1610420-28-4 (Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a CB1R/iNOS dual-targeting inhibitor (antagonist) with a Ki of 5.7 nM for CB1R.
(Rac)-ZLc-002 V77363 (Rac)-ZLc-002 (Rac)-ZLc-002 is an inhibitor (blocker/antagonist) of the interaction between nNOS and nitric oxide synthase 1 adapter protein (NOS1AP), inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergizes with Paclitaxel to reduce tumor cell viability.
(S)-ZLc002 V75092 (S)-ZLc002 308277-46-5 (S)-ZLc002 is the S-enantiomer of ZLc-002.
1,3-PBIT dihydrobromide V102009 1,3-PBIT dihydrobromide 200716-66-1 1,3-PBIT is a potent inhibitor of iNOS with a Ki value of 47 nM, while the Ki values for eNOS and nNOS in purified human enzymes are 9 and 0.25 μM, respectively.
1-Heptadecanoyl-rac-glycerol V90910 1-Heptadecanoyl-rac-glycerol 5638-14-2 1-Heptadecanoyl-rac-glycerol (1-Heptadecanoin) is a glyceride compound with anti-inflammatory activity.
1-O-Caffeoylglycerol V116746 1-O-Caffeoylglycerol 123134-23-6 1-O-Caffeoylglycerol is a compound with anti-inflammatory activity found in sorghum (Sorghum bicolor).
12-Acetoxyganoderic acid D V106016 12-Acetoxyganoderic acid D 2374206-92-3 12-Acetoxyganoderic acid D is a triterpenoid found in Ganoderma lucidum.
1400W (W1400) V84184 1400W (W1400) 180001-34-7 1400W is a slow, tight binding, highly selective inducible nitric oxide synthase (iNOS) inhibitor
2′-Hydroxy-2,3-dimethoxychalcone V96926 2′-Hydroxy-2,3-dimethoxychalcone 42220-80-4 α-Gracinoic acid is a chalcone derivative with anti-inflammatory activity.
2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone V112479 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone 123999-38-2 2,4-Dihydroxy-6-methoxy-3,5-diisopentenylacetophenone (compound 8) is an acetophenone derivative found in *Acronychia oligophlebia*.
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