IRAK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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IRAK

Through their function in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling pathways, interleukin-1 receptor-associated kinases (IRAKs), which are serine/threonine kinases, play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers. Two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M, are among the four distinct IRAK-like molecules that have been discovered. Nuclear factor-kappaB (NF-B) and mitogen-activated protein kinase (MAPK) pathways are both activated by all IRAKs.

The adaptor molecule MyD88 and the IRAK-1, 2, M, and 4 members of the IL-1R-associated kinase family are used by toll-like receptors to transmit their signals. The Myddosomes formed by MyD88-IRAK-4, IRAK-1, and IRAK-2 are known to mediate TLR7-induced, TAK1-dependent NF-B activation. It is known that IRAK-M acts as a negative regulator, preventing the dissociation of IRAKs from MyD88 and obstructing subsequent signaling.

IRAK related products

Cat No.	Product Name	CAS No.	Product Description
V22652	IRAK-1/4 Inhibitor	509093-47-4	IRAK-1-4 Inhibitor I is an IRAK1/4 inhibitor (antagonist) with IC50 of 0.2 μM and 0.3 μM respectively.
V86890	BIO-7488	2573211-25-1	BIO-7488 is a potent, selective, orally active and blood-brain barrier permeable IRAK4 inhibitor with IC50 values of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively.
V86889	BIO-8169	2792153-06-9	BIO-8169 is a selective inhibitor of interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 0.23 nM.
V114564	BMS-978299	1610016-88-0	BMS-978299 is an IRAK4 inhibitor that can be used in research on immune diseases.
V86885	DW18134	2626988-87-0	DW18134 is an inhibitor of interleukin receptor-associated kinase 4 (IRAK 4) with IC50 of 11.2 nM.
V40494	Emavusertib (CA-4948)	1801344-14-8	Emavusertib (CA-4948) is a first-in-class, orally bioactive and highly potent IRAK4/FLT3 inhibtor (IC50 of < 50 nM) with anticancer activity.
V103102	Emavusertib maleate	2376399-39-0	Emavusertib maleate (CA-4948 maleate) is the maleate salt form of Emavusertib.
V103103	Emavusertib phosphate	2376399-38-9	Emavusertib phosphate (CA-4948 phosphate) is the phosphate form of Emavusertib.
V103101	Emavusertib tosylate	2376399-41-4	Emavusertib mesylate (CA-4948 mesylate) is the mesylate salt form of Emavusertib.
V118691	FIP22	3091132-73-6	FIP22 is a highly efficient and selective IRAK4 PROTAC degrader (HEK293T cells: DC50 = 3.2 nM; THP-1 cells: DC50 = 10.6 nM).
V75059	GLPG2534	2095615-97-5	GLPG2534 is an orally bioactive and selective IRAK4 inhibitor (antagonist) with IC50s of 6.4 nM and 3.5 nM for human and mouse IRAK4.
V118274	GLPG4471	2499855-36-4	GLPG4471 is a highly selective, orally effective IRAK4 inhibitor with an IC50 value of 1.7 nM.
V75066	GNE-2256	2102170-43-2	GNE-2256 (molecule 19) is an orally bioactive IRAK4 (interleukin 1 receptor-associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM).
V75064	HS271	2410393-15-4	HS271 is a potent, orally bioactive, and selective IRAK4 inhibitor (antagonist) with IC50 of 7.2 μM.
V34066	IRAK inhibitor 1	1042224-63-4	IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
V75063	IRAK inhibitor 4 (trans)	2070014-89-8	IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4, which is a potent inhibitor of IRAK4.
V6791	IRAK-IN-6	1042672-97-8	IRAK-IN-6, formerly known as IRAK inhibitor 6, is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor.
V75062	IRAK-4 protein kinase inhibitor 2	301675-24-1	IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK-4) with IC50 of 4 μM.
V86892	IRAK1-IN-1		IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor.
V103703	IRAK1/4/pan-FLT3 Kinase-IN-1	2760328-82-1	IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent IRAK1, IRAK4 and FLT3 kinase inhibitor with IC50 of 5 and 0.6 nM for IRAK1 and IRAK4, respectively, and IC50 of less than 0.5 nM for FLT3.