Complement System

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Complement System

The complement system, which is made up of more than 30 serum and cell surface components, works with the innate and acquired immune systems to recognize and get rid of pathogens. Following the activation of the complement system, a series of events involving proteolysis and assembly lead to the cleavage of the third complement component (C3). The activation pathway refers to the cascade that leads to C3 cleavage. The classical, lectin, and alternative pathways are the three types of activation.

The complement cascade is a double-edged sword that causes phagocytosis and inflammation while also providing defense against viral and bacterial invasion. If complement is not properly controlled, it can cause significant pathological damage to erythrocytes (hemolysis), kidney basement membrane and attached endothelial and epithelial cells (nephritis), joint synovium (arthritis), and blood vessels (vasculitis).

Complement System related products

Cat No.	Product Name	CAS No.	Product Description
V74793	3-O-(2'E,4'Z-Decadienoyl)ingenol (3-O-(2'E,4'Z-Decadienoyl) ingenol)	84680-59-1	3-O-(2'E,4'Z-Decadienoyl)ingenol is a naturally occurring diterpene with significant anti-complement activity with IC50 of 89.5 μM.
V74774	3-Phenoxybenzaldehyde (m-Phenoxybenzaldehyde)	39515-51-0	3-Phenoxybenzaldehyde has weak inhibitory activities on the classical pathway of complement and hemolytic activity.
V109031	[DArg10, Aib20] TLQP-21		[DArg10, Aib20] TLQP-21 is an analogue of TLQP-21 and is a partial agonist and antagonist of C3aR (recruited via β-arrestin, EC50 of 854 nM).
V109154	[DArg10, DAla20] TLQP-21		[DArg10, DAla20] TLQP-21 is an analogue of TLQP-21, a C3aR agonist (EC50 value of β-arrestin recruitment is 87 nM).
V127991	A7RC	632358-46-4	A7RC is a multifunctional peptide for targeted cancer therapy, with a cysteine residue added to its C-terminus (sequence: ATWLPPR).
V114441	ACT-1014-6470	2363082-87-3	ACT-1014-6470 is an orally effective, reversible, selective C5aR1 antagonist.
V37572	ADH-503 [(Z)-Leukadherin-1 choline]	2055362-74-6	ADH-503[(Z)-Leukadherin-1 choline] is a novel, potent, selective, orally bioactive and allosteric agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
V40131	ADH-503 free base	2055362-72-4	ADH-503 free base [(Z)-Leukadherin-1]is a novel, potent, selective,orally bioactive and allostericagonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
V116777	Agazisiran	2985646-78-2	Agazisiran is a siRNA that inhibits the synthesis of complement factor B.
V116779	Agazisiran sodium		Sodium agazisiran is a siRNA that inhibits the synthesis of complement factor B.
V128392	Agazisiran sodium scrambled negative control		The Agazisiran sodium scrambled negative control is a negative control with the sequence of Agazisiran sodium scrambled.
V128438	AKIR001		AKIR001 is a high-affinity human IgG1 antibody that targets CD44v6.
V129207	ANX-M1 (Human IgG1)		ANX-M1 (Human IgG1) is an anti-C1q antibody that can cross the blood-brain barrier.
V77244	ARC186		ARC 186 is a nucleic acid aptamer and a potent complement inhibitor that works by blocking C5 activation catalyzed by invertase.
V86833	ARC186 sodium		ARC186 (sodium) is a PEGylated nucleic acid aptamer.
V129491	Ascuprubart	3056020-15-3	Ascuprubart is an anti-human monoclonal antibody that targets complement C5.
V129511	ASP-1948		ASP-1948 is a human monoclonal antibody (mAb) that targets NRP1/VEGF165R/CD34.
V129630	ATR-IN-27	1613196-89-6	ATR-IN-27 is an ATR inhibitor with a Ki value greater than 0.01 μM but less than 1 μM.
V77228	ATWLPPR Peptide TFA		ATWLPPR Peptide TFA is a selective neuropilin-1 (NRP-1) inhibitor that can inhibit the binding of VEGF165 to NRP-1 and can be used for angiogenesis research.
V74790	Avacincaptad pegol	1613641-69-2	Avacincaptad pegol (Izervay) is a nucleic acid aptamer that works as a C5 complement inhibitor to reduce inflammation-related retinal pigment epithelial (RPE) damage.