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Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor

The basic helix-loop-helix transcription factor family includes the cytoplasmic receptor and transcription factor known as aryl hydrocarbon receptor (AhR or AHR). Exogenous and endogenous ligands of various types can either activate or inhibit the AhR. When it comes to immunity and tissue homeostasis, AhR plays a crucial role. A variety of structurally different substances, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can activate AhR.

Indigooids, heme metabolites, eicosanoids, tryptophan derivatives, and equilenin are examples of endogenous ligands. Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, natural substances, and small molecule substances are examples of exogenous ligands. Because AhR ligands differ in their shapes and characteristics, their interactions with AhR have unique biological effects.

Hsp90, AIP, and p23 are examples of chaperone proteins that sequester unliganded AHR in the cytoplasm. AHR moves into the nucleus after ligand binding and forms a heterodimer with ARNT. The aryl hydrocarbon response elements, which are found in the regulatory regions of target genes like CYP1A1, CYP1B1, and TIPARP, are where the AHR-ARNT complex regulates transcription by binding with high affinity.

Aryl Hydrocarbon Receptor related products

Structure Cat No. Product Name CAS No. Product Description
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin V107169 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (1,2,3,6,7,8-HxCDD) is an AHR agonist with EC50 values of 5.4 nM and 9.3 nM at 4 and 8 hours, respectively, in a reporter gene assay.
1,2,3,7,8,9-Hexachlorodibenzofuran V105104 1,2,3,7,8,9-Hexachlorodibenzofuran 72918-21-9 1,2,3,7,8,9-Hexachlorodibenzofuran is a homologue of polychlorinated dibenzofurans.
1,4-Dihydroxy-2-naphthoic acid V86803 1,4-Dihydroxy-2-naphthoic acid 31519-22-9 1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist.
12(R)-HETE V86798 12(R)-HETE 82337-46-0 12(R)-HETE is a metabolite of arachidonic acid, AA, which is found in psoriasis lesions.
3-OH-Kynurenamine V74745 3-OH-Kynurenamine 99362-47-7 3-OH-Kynurenamine is a lateral metabolite in the metabolism of Tryptophan.
3-OH-Kynurenamine dihydroiodide V86805 3-OH-Kynurenamine dihydroiodide 2155855-77-7 3-OH-Kynurenamine dihydroiodide is the dihydroiodide salt of 3-OH-Kynurenamine.
6,2',4'-三甲氧基黄酮 V51688 6,2',4'-Trimethoxyflavone 720675-74-1 6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist.
AHR agonist 4 V80526 AHR agonist 4 2953023-30-6 AHR agonist 4 (compound 24e) is an agonist of the aryl hydrocarbon receptor AHR and is related to the immune balance of Th17/22 and Treg cells.
AhR agonist 5 V103543 AhR agonist 5 AhR agonist 5 is an AHR agonist (EC50 = 6 nM).
AhR agonist 6 V86801 AhR agonist 6 3033281-96-5 AhR agonist 6 (Compound 6) is an agonist of aryl hydrocarbon receptor (AHR) with EC50 of 0.01 nM.
AhR agonist 7 V86800 AhR agonist 7 3033281-98-7 AhR agonist 7 (Compound 8) has a strong activating activity on AhR (ECsub>50=13 nM).
AhR agonist 8 V97188 AhR agonist 8 3036895-67-4 AhR agonist 8 (Compound 9) is a potent aryl hydrocarbon receptor (AhR) agonist with EC50 of 0.154 nM.
AHR antagonist 5 hemimaleate V78602 AHR antagonist 5 hemimaleate AHR antagonist 5 hemimaleate is a potent, orally bioactive aryl hydrocarbon receptor (AHR) antagonist (inhibitor) with IC50 of < 0.5 μM.
AHR antagonist 6 V84334 AHR antagonist 6 378223-81-5
AHR-IN-1 V104767 AHR-IN-1 2247951-12-6 AHR-IN-1 (1-103) is an aryl hydrocarbon receptor (AHR) inhibitor with IC50 < 0.5 μM.
Carbidopa hydrochloride V94231 Carbidopa hydrochloride 65132-60-7 Carbidopa hydrochloride ((S)-(-)-carbidopa hydrochloride) is a drug used to inhibit Parkinson's disease. It has the activity of inhibiting the peripheral metabolism of levodopa. Carbidopa hydrochloride can increase the proportion of peripheral levodopa passing through the blood-brain barrier, thereby enhancing its effect on the central nervous system.
Carbidopa-d3 monohydrate V51696 Carbidopa-d3 monohydrate 1276197-58-0 Carbidopa-d3 (monohydrate) is the deuterated form of carbidopa monohydrate.
CAY10464 V86799 CAY10464 688348-37-0 CAY10464 (AHR antagonist 7; compound 4j) is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with Ki of 1.4 nM.
CAY10465 V3994 CAY10465 688348-33-6 CAY 10465, an analog of resveratrol, is a novel, potent, selective and high-affinityAhR (aryl hydrocarbon receptor) agonist, with aKiof 0.2 nM, and shows no effect on estrogen receptor (Ki>100000 nM).
CB7993113 V84310 CB7993113 819827-50-4
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