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PD-1 PD-L1

PD-1 PD-L1

A cell surface receptor called Programmed Death-1 (PD-1) serves as a T cell checkpoint and is crucial in controlling T cell exhaustion. PDL-1 or PDL-2 engagement with PD-1 causes it to become active. When the PD-1 receptor binds to its ligands, PD-L1 and PD-L2, which are expressed on cancer cells and antigen-presenting cells, it sends inhibitory checkpoint signals to activated T cells. This suppresses T-cell effector function and allows tumor immune evasion. An appealing approach for tumor immunotherapy is to block the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway.

Activated T cells, B cells, monocytes, dendritic cells, regulatory T cells, and natural killer T cells all express PD-1. It belongs to a group of immunoglobulin domain (Ig) co-receptors that affect how the T cell receptor responds when activated by an antigen-presenting cell (APC) or an infected target cell. In contrast to PD-L2, which is only and inducibly expressed on professional APCs, PD-L1 is widely expressed and constitutively on both hematopoietic and nonhematopoietic cells, including naive T and B cells, vascular endothelial cells, and pancreatic islet cells.

PD-1 PD-L1 related products

Structure Cat No. Product Name CAS No. Product Description
CP21 V36345 CP21 CP21is a bifunctional immunomodulatory small molecule targeting PD-L1 and CXCL12 with high affinities.
CSN5-IN-1 V98360 CSN5-IN-1 CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively.
CVRARTR V86964 CVRARTR 2349354-64-7 CVRARTR is an antagonist of programmed cell death ligand 1 (PD-L1) with a KD of 281 nM.
CYP51/PD-L1-IN-1 V78968 CYP51/PD-L1-IN-1 3032386-49-2 CYP51/PD-L1-IN-1 (compound L11) is a quinazoline compound with antifungal activity.
CYP51/PD-L1-IN-2 V78904 CYP51/PD-L1-IN-2 3032386-58-3 CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity.
CYP51/PD-L1-IN-3 V78665 CYP51/PD-L1-IN-3 3032386-59-4 CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity.
CYP51/PD-L1-IN-4 V78667 CYP51/PD-L1-IN-4 CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor (antagonist) with IC50s of 0.17 and 0.021 μM, respectively.
Danvilostomig V86971 Danvilostomig Danvilostomig is an anti-CTLA4/PDCD1 monoclonal antibody.
Enristomig V86967 Enristomig Enristomig is an anti-TNFRSF9/CD274 monoclonal antibody.
EP26 V86957 EP26 EP26 is a potent and orally active inhibitor of EGFR and PD-L1 with IC50 values of 48.6 nM and 1.77 µM, respectively.
Fanastomig V86897 Fanastomig Fanastomig is a monoclonal antibody against PDCD1/LAG3.
HBV/HDV-IN-1 V86962 HBV/HDV-IN-1 3034161-55-9 HBV/HDV-IN-1 (Compd 122) is an inhibitor of HBV, HDV and PD-1/PD-L1 with EC50 values of 8 nM and 35 nM for T cell activation and PD-L1 internalization, respectively.
HBV/HDV-IN-2 V86966 HBV/HDV-IN-2 3034161-76-4 HBV/HDV-IN-2 (Compd 143) is an inhibitor of HBV, HDV and PD-1/PD-L1 with an EC50 of 35 nM for T cell activation.
Human PD-L1 inhibitor V TFA V76906 Human PD-L1 inhibitor V TFA Human PD-L1 inhibitor V TFA is a human PD-1 protein binding peptide with a Kd of 3.32 μM, which can inhibit the binding of human PD-1/PD-L1.
Ir-UA V86955 Ir-UA 3033235-42-3 Ir-UA is a usnic acid-derived iridium(III) complex that can enhance PD-L1 expression and convert “cold tumors” into “hot tumors.” Ir-UA stimulates PD-L1 expression by explicitly regulating the PD-L1 transcription factor.
LLW-018 V86958 LLW-018 LLW-018 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 2.61 nM.
Lomvastomig V86940 Lomvastomig Lomvastomig is a human IgG1 kappa monoclonal antibody against PDCD1/HAVCR2.
LP23 V78598 LP23 3008239-25-3 LP23 is a non-arylmethylamine PD-1/PD-L1 PPI inhibitor (IC50= 16.7 nM) with anti-tumor activity.
LTB V104675 LTB LTB is a prodrug formed by coupling a glycolysis inhibitor (lonidamine) and a PD1/PDL1 blocker (BMS-1) through a thioketal bond, which can be further coated with the photosensitizer chlorine e6 (Ce6) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) through self-assembly.
LZFPN-90 V86946 LZFPN-90 LZFPN-90 (LZ90) is a NAMPT/PD-L1 dual-targeting compound.
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