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Caspase

Caspase

An important part of apoptosis (programmed cell death), necrosis, and inflammation is played by the cysteine protease family known as caspase. Apoptotic caspases come in two varieties: effector (executioner) caspases and initiator (apical) caspases. Effector caspases are activated when initiator caspases, such as CASP2, CASP8, CASP9, and CASP10, cleave their inactive pro-forms. In order to start the apoptotic process, effector caspases (such as CASP3, CASP6, and CASP7) cleave other protein substrates inside the cell. Caspase inhibitors control how this cascade reaction gets started. Because they are inflammatory enzymes that cooperate with CASP1 to play a role in T-cell maturation, CASP4 and CASP5, which are overexpressed in some cases of vitiligo and related autoimmune diseases brought on by NALP1 variants, are not currently classified as initiators or effectors in MeSH.

Caspase related products

Structure Cat No. Product Name CAS No. Product Description
2-HBA V33252 2-HBA 131359-24-5 2-HBA, ananalog of curcumin,is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
Ac-AAVALLPAVLLALLAP-LEVD-CHO V76052 Ac-AAVALLPAVLLALLAP-LEVD-CHO 886462-82-4 Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-penetrating/penetrable caspase-4 inhibitor (antagonist) with anti-tumor activity.
Ac-AAVALLPAVLLALLAP-YVAD-CHO V76050 Ac-AAVALLPAVLLALLAP-YVAD-CHO 201608-12-0 Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-penetrating/penetrable caspase-1 inhibitor (antagonist) with anti-tumor activity.
Ac-DEVD-CHO V2777 Ac-DEVD-CHO 169332-60-9 Ac-DEVD-CHO is a potent and specific aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively.
Ac-DEVD-CMK TFA (Caspase-3 Inhibitor III TFA) V77300 Ac-DEVD-CMK TFA (Caspase-3 Inhibitor III TFA) Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor.
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) V75995 Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) 775289-20-8 Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50= 9.89, 245 nM, respectively; Kiapp: 0.68, 55.7 nM, respectively).
Ac-VAD-pNA V75996 Ac-VAD-pNA 154564-07-5 Ac-VAD-pNA is a caspase-1 substrate.
Ac-VDVAD-pNA V75998 Ac-VDVAD-pNA 189684-53-5 Ac-VDVAD-pNA is a caspase-2 substrate.
Ac-VETD-AMC V75997 Ac-VETD-AMC 1135686-24-6 Ac-VETD-AMC is a synthetic peptide substrate for caspase 8.
Ac-WEHD-AFC TFA V77291 Ac-WEHD-AFC TFA Ac-WEHD-AFC TFA is a fluorescent caspase-1 substrate.
Ac-YVAD-FMK V106138 Ac-YVAD-FMK 350021-87-3 Ac-YVAD-FMK is an inhibitor of caspase 1 proteases.
ALK-IN-26 V69263 ALK-IN-26 2447607-85-2 ALK-IN-26 (compound 4a) is an ALK inhibitor (antagonist) with IC50 of 7.0 μM for ALK tyrosine kinase.
Antiproliferative agent-42 V80024 Antiproliferative agent-42 antiproliferation agent-42 (compound 7m) is a dihydrodipyrrole compound.
Apoptosis inducer 34 V102673 Apoptosis inducer 34 582314-48-5 Apoptosis inducer 34 (compound 4) is a small molecule compound that induces apoptosis by directly activating the basal apoptotic machinery.
ATWLPPRAANLLMAAS V106281 ATWLPPRAANLLMAAS 1228447-26-4 ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects.
Belnacasan (VX765) V0024 Belnacasan (VX765) 273404-37-8 Belnacasan (also known as VX-765) is a novel, potent, selective and orally bioactive prodrug of VRT-043198 which is a potent and selective inhibitor of caspase-1 withKi values of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively.
BEPP hydrochloride V102462 BEPP hydrochloride 455311-98-5 BEPP hydrochloride is a double-stranded RNA-dependent protein kinase (PKR) inducer and antiviral agent.
Bfl-1-IN-6 V105053 Bfl-1-IN-6 Bfl-1-IN-6 (Compound 20) is an orally active Bcl-2-related protein A1 (BFL1) inhibitor with IC50 of 19 nM.
BOC-D-FMK V29824 BOC-D-FMK 634911-80-1 Boc-D-FMK is a cell-permeable, irreversible (covalent) and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
C105SR V78588 C105SR C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl prolyl trans-isomerase (PPIase).
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