An important part of apoptosis (programmed cell death), necrosis, and inflammation is played by the cysteine protease family known as caspase. Apoptotic caspases come in two varieties: effector (executioner) caspases and initiator (apical) caspases. Effector caspases are activated when initiator caspases, such as CASP2, CASP8, CASP9, and CASP10, cleave their inactive pro-forms. In order to start the apoptotic process, effector caspases (such as CASP3, CASP6, and CASP7) cleave other protein substrates inside the cell. Caspase inhibitors control how this cascade reaction gets started. Because they are inflammatory enzymes that cooperate with CASP1 to play a role in T-cell maturation, CASP4 and CASP5, which are overexpressed in some cases of vitiligo and related autoimmune diseases brought on by NALP1 variants, are not currently classified as initiators or effectors in MeSH.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V121824 | (Iso)-Z-VAD(OMe)-FMK | 634911-81-2 | (Iso)-Z-VAD(OMe)-FMK is an isomer of the caspase and UCL1 inhibitor Z-VAD(OMe)-FMK. |
|
V112017 | 2-Et-AZT | 1995864-97-5 | 2-Et-AZT is a modified azidothymidine. |
|
V33252 | 2-HBA | 131359-24-5 | 2-HBA, ananalog of curcumin,is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10. |
|
V126117 | 4′-O-Methylglabridin | 68978-09-6 | 4′-O-Methylglabridin is an apoptosis inducer with antioxidant, cell cycle arrest, and anticancer cytotoxic activities. |
|
V125988 | 4,4′-Secalonic acid D | 2265910-52-7 | 4,4′-Secalonic acid D is a PARP1 inhibitor. |
|
V127432 | 6-Methoxydihydrosanguinarine hydrochloride | 6-Methoxydihydrosanguinarine hydrochloride is an alkaloid that is active against a variety of cancer cell types. | |
|
V76052 | Ac-AAVALLPAVLLALLAP-LEVD-CHO | 886462-82-4 | Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-penetrating/penetrable caspase-4 inhibitor (antagonist) with anti-tumor activity. |
|
V76050 | Ac-AAVALLPAVLLALLAP-YVAD-CHO | 201608-12-0 | Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-penetrating/penetrable caspase-1 inhibitor (antagonist) with anti-tumor activity. |
|
V128062 | Ac-AAVALLPAVLLALLAPVAD-CHO TFA | Ac-AAVALLPAVLLALLAPVAD-CHO TFA is a complex of Ac-VAD-CHO. | |
|
V2777 | Ac-DEVD-CHO | 169332-60-9 | Ac-DEVD-CHO is a potent and specific aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. |
|
V128074 | Ac-DEVD-CHO TFA | Ac-DEVD-CHO TFA is a peptide inhibitor of caspase-3 (Ki=230 pM) and caspase-7. | |
|
V77300 | Ac-DEVD-CMK TFA (Caspase-3 Inhibitor III TFA) | Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. | |
|
V128076 | Ac-DMLD-CMK | 2588354-33-8 | Ac-DMLD-CMK is a caspase 3 inhibitor and a GSDME inhibitor. |
|
V118514 | Ac-DMLD-CMK TFA | Ac-DMLD-CMK TFA is a peptide that targets the mouse caspase 3-Gsdme signaling pathway. | |
|
V128077 | Ac-DMQD-AMC TFA | Ac-DMQD-AMC TFA is a fluorescent substrate for caspase-3 or caspase-10. | |
|
V75995 | Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) | 775289-20-8 | Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50= 9.89, 245 nM, respectively; Kiapp: 0.68, 55.7 nM, respectively). |
|
V128192 | Ac-IETD-AFC TFA | Ac-IETD-AFC TFA is a synthetic fluorescent substrate that can be used to specifically detect caspase-8 activity. | |
|
V128195 | Ac-LEVD-CHO TFA | Ac-LEVD-CHO TFA is a caspase-4 inhibitor. | |
|
V128270 | Ac-VAD-AFC | Ac-VAD-AFC is a fluorescent substrate for caspase and can be used to detect caspase activity. | |
|
V75996 | Ac-VAD-pNA | 154564-07-5 | Ac-VAD-pNA is a caspase-1 substrate. |
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