The genetic material (DNA or RNA) of viral pathogens contains enzymes called viral proteases. Viral proteases catalyze the cleavage of particular peptide bonds in cellular proteins or viral polyprotein precursors. Viral proteases may attack the scissile peptide bond using various catalytic mechanisms involving either serine, cysteine, or aspartic acid residues. A high degree of specific recognition and cleavage is guaranteed by the enzyme's complementary substrate binding site's selective recognition of these sequence patterns.
The respiratory illness coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 coronavirus (SARS-CoV-2). SARS-CoV-2 entry requires transmembrane protease, serine 2 (TMPRSS2) to prime the initial spike protein. The cell's protease TMPRSS2 breaks open the virus's spike protein after a SARS-CoV-2 virion attaches to a target cell, revealing a fusion peptide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52846 | (+)-JNJ-A07 | 2135640-93-4 | (+)-JNJ-A07 is a potent pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. |
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V52506 | (E)-3,4-Dimethoxycinnamic acid ((E)-3,4-Dimethoxycinnamic acid; (E)-O-Methylferulic acid) | 14737-89-4 | (E)-3,4-Dimethoxycinnamic acid is a less active isomer of 3,4-Dimethoxycinnamic acid. |
|
V113232 | (R,S)-STT3A/B-IN-1 | 3067185-00-3 | (R,S)-STT3A/B-IN-1 (compound 32) is a racemic mixture of STT3A/B-IN-1 and is an STT3A/B inhibitor. |
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V54448 | 2'-Deoxy-2'-fluoro-l-uridine | 622785-69-7 | 2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. |
|
V109796 | 2-Deoxy-2-fluoro-D-mannose | 38440-79-8 | 2-Deoxy-2-fluoro-D-mannose is an antiviral mannose analog that inhibits the formation of oligosaccharide chains during protein glycosylation. |
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V52961 | 2-Hydroxy-4-methylbenzenesulphonic acid ammonium | 79093-71-3 | 2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity in Policyresulen. |
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V54444 | 4-Hydroxy-2-methylbenzenesulfonic acid ammonium | 2742982-16-5 | 4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity in Policyresulen. |
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V52748 | 4-Methylanisole-d3 (4-Methoxytoluene-d3) | 14202-49-4 | 4-Methylanisole-d3 is the deuterium labelled form of 4-Methylanisole. |
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V52751 | 4-Phenylbutyric acid-d11 (4-PBA-d11; Benzenebutyric acid-d11) | 358730-86-6 | 4-Phenylbutyric acid-d11 is the deuterated form of 4-Phenylbutyric acid. |
|
V52750 | 4-Phenylbutyric acid-d2 (4-PBA-d2; Benzenebutyric acid-d2) | 461391-24-2 | 4-Phenylbutyric acid-d2 is the deuterated form of 4-Phenylbutyric acid. |
|
V52749 | 4-Phenylbutyric acid-d5 (4-PBA-d5; Benzenebutyric acid-d5) | 64138-52-9 | 4-Phenylbutyric acid-d5 is the deuterated form of 4-Phenylbutyric acid. |
|
V54443 | 5-Bromo-2′-deoxy-2′-fluorouridine | 55612-18-5 | 5-Bromo-2′-deoxy-2′-fluorouridine (Example 1) is a 5-halogen analog with potential use as an antiviral compound. |
|
V77588 | 5-Hydroxytoluene-2,4-disulphonic acid diammonium | 5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity in Policyresulen. | |
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V52464 | A2ti-1 | 570390-00-0 | A2ti-1 is a selective, high-affinity inhibitor of the annexin A2/S100A10 heterotetramer (A2t) with IC50 of 24 μM. |
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V52463 | A2ti-2 | 482646-13-9 | A2ti-2 is a selective, low-affinity inhibitor of the annexin A2/S100A10 heterotetramer (A2t) with IC50 of 230 μM. |
|
V88337 | Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate | Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate is the acetate form of Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr. | |
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V116291 | AG-1859 | 478410-84-3 | AG-1859 is a viral protease inhibitor that can be used in viral infection research. |
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V54445 | AG-7404 | 343565-99-1 | AG-7404 is a picornavirus 3C protease inhibitor (antagonist) with anti-poliovirus activity (EC50=0.080-0.674 μM). |
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V106306 | AH-D peptide | AH-D peptide is an antiviral peptide that selectively disrupts the membrane envelope structure within the exosome size range, induces T-EXO depletion and enhances cancer immunotherapy. | |
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V118455 | AH-D peptide TFA | AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures across a wide range of exosome sizes, inducing T-EXO depletion and enhancing cancer immunotherapy. |
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