The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81552 | Telaprevir-d4 (VX-950-d4) | Telaprevir-d4 is the deuterium labelled form of Telaprevir. | |
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V101423 | Timcevibart | Timcevibart is a human IgG1 kappa monoclonal antibody directed against SARS-CoV-2. | |
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V52568 | Tipranavir-d4 (tipranavir d4) | 1217819-15-2 | Tipranavir-d4 is the deuterium labelled form of Tipranavir. |
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V54340 | tirfipiravir | 2759996-93-3 | Tirfipiravir is a nucleoside compound and antiviral compound that works against the novel coronavirus or influenza virus. |
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V54422 | TKB245 | 2892688-16-1 | TKB245 is a potent SARS-CoV-2 Mpro inhibitor that effectively blocks SARS-CoV-2 replication in VeroE6 cells. |
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V106303 | UCI-1 | UCI-1 is a cyclic peptide inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 160 μM. | |
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V81669 | Umifenovir-d6 hydrochloride (Arbidol d6 hydrochloride (hydrochloride)) | 2928218-29-3 | Umifenovir-d6 ( HCl) is the deuterium labelled form of Umifenovir HCl. |
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V99022 | UNI418 | 1802068-51-4 | UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with anti-SARS-CoV-2 viral activity (EC50=1.4 μM). |
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V35076 | Viral polymerase-IN-1 hydrochloride | 2367587-02-6 | Viral polymerase-IN-1 HCl is a Gemcitabine analogue that effectively inhibits influenza A and B virus (influenza) infection with an IC90 value of 11.4-15.9 μM. |
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V101282 | Virapinib | 1794091-10-3 | Vilatinib is a macropinocytosis inhibitor with antiviral activity. |
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V54415 | WU-04 | 2921711-74-0 | WU-04 is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. |
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V76073 | X77 | 2455518-33-7 | X77 is a potent non-covalent inhibitor of SARS-CoV-2 protease (SARS-CoV-2 Mpro). |
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V104927 | XJ5 | XJ5 is a non-nucleoside covalent inhibitor of Nsp12 (IC50=0.12 μM), which is the nonstructural protein 12 of the virus. | |
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V38794 | XP-59 | 890402-73-0 | XP-59 is a potent SARS-CoV Mpro inhibitor (antagonist) with Ki of 0.1 nM. |
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V54403 | XR8-69 | 2817811-10-0 | XR8-69 is a SARS-CoV-2 PLpro inhibitor that displays low micromolar antiviral potency in SARS-CoV-2-infected human cells. |
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V76075 | XR8-89 | 2817811-16-6 | XR8-89 is a potent papain-like (PLpro) inhibitor (antagonist) with IC50 of 0.1 μM. |
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V54398 | Z-Arg-Leu-Arg-Gly-Gly-AMC | 167698-69-3 | Z-Arg-Leu-Arg-Gly-Gly-AMC is a bioactive peptide substrate of SARS-CoV PLpro. |
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V93175 | Z-Arg-Leu-Arg-Gly-Gly-AMC acetate | Z-Arg-Leu-Arg-Gly-Gly-AMC acetate is a peptide substrate for SARS-CoV PLpro. | |
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V73065 | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) | 371167-61-2 | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. |
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V35097 | Z-LVG-CHN2 | 119670-30-3 | Z-LVG-CHN2 is an intracellular irreversible inhibitor of cysteine protease. |
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