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HIV

HIV

The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.

HIV related products

Structure Cat No. Product Name CAS No. Product Description
(+)-PM 92131 V118607 (+)-PM 92131 167937-11-3 (+)-PM 92131 is the active enantiomer of (±)-PM 92131.
(-)-Rabdosiin V54276 (-)-Rabdosiin 119152-54-4 (-)-Rabdosiin is a novel phenolic marker discovered from Symphytum officinale L.
(2RS)-FPMPA V54273 (2RS)-FPMPA 135295-27-1 (2RS)-FPMPA may be utilized to prepare antiretroviral reagents against HIV-1 and HIV-2.
(2S,5S)-Censavudine ((2S,5S)-OBP-601; (2S,5S)-BMS-986001) V77391 (2S,5S)-Censavudine ((2S,5S)-OBP-601; (2S,5S)-BMS-986001) (2S,5S)-Censavudine ((2S,5S)-OBP-601) is the (2S,5S)-enantiomer of Censavudine.
(D-Ala)-Peptide T V113210 (D-Ala)-Peptide T 106362-33-8 (D-Ala)-peptide T is an octapeptide derived from gp120.
(R,R)-Abacavir V117664 (R,R)-Abacavir 1443421-67-7 (R,R)-Abacavi is the (R,R)-enantiomer of abacavi.
(Rac)-Emtricitabine S-oxide V113349 (Rac)-Emtricitabine S-oxide 2733287-29-9 (Rac)-Emtricitabine S-oxide ((Rac)-Emtricitabine sulfoxide; (Rac)-Emtricitabine degradation product-III) is a racemic mixture of emtricitabine S-oxide.
(S)-替诺福韦 V40146 (S)-Tenofovir 147127-19-3 (S)-Tenofovir [known also as (S)-GS 1278], the S-enantiomer of Tenofovir and a less active isomer,is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV).
(Z)-9-Propenyladenine ((Z)-替诺福韦酯杂质; (Z)-Mutagenic Impurity of Tenofovir Disoproxil) V53005 (Z)-9-Propenyladenine ((Z)-Mutagenic Impurity of Tenofovir Disoproxil) 1464851-21-5 (Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
(±)-PM 92131 V118678 (±)-PM 92131 124070-99-1 (±)-PM 92131 is a non-nucleoside HIV-1 inhibitor.
019854-B06 V110897 019854-B06 019854-B06 is a potent Tat-mediated HIV-1 transcriptional inhibitor (IC50 = 1.44 μM) with anti-HIV-1 viral activity (EC50 = 0.83 μM).
12-Bromododecanoic acid V106882 12-Bromododecanoic acid 73367-80-3 12-Bromododecanoic acid is a bromo fatty acid.
12-Methoxydodecanoic acid V101476 12-Methoxydodecanoic acid 92169-28-3 12-Methoxydodecanoic acid is a heteroatom-containing myristic acid analogue with anti-HIV activity with IC50 of 6.8 μM.
148.1-38m sodium V116368 148.1-38m sodium Sodium 148.1-38m is an RNA nucleic acid aptamer that can inhibit the reverse transcriptase (RT) activity of HIV-1, interfering with the viral replication process.
2'-Deoxy-2'-fluoroarabinoadenosine V88714 2'-Deoxy-2'-fluoroarabinoadenosine 20227-41-2 2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analog with antiviral activity against human immunodeficiency virus (HIV).
2,4-Dihydroxypyridine V107844 2,4-Dihydroxypyridine 626-03-9 2,4-Dihydroxypyridine (Compound 2) is a pyridine derivative that has inhibitory activity against both Topo IIKHIV activity and HIV-1 replication, with pIC50 values of 5.05 and 4.07 for Topo IIKHIV and HIV-1 replication, respectively.
2-Bromoaldisine V91149 2-Bromoaldisine 96562-96-8 2-Bromoaldisine is a pyrrole alkaloid isolated from Stylissa carter.
2F5 epitope V54297 2F5 epitope 470704-11-1 The 2F5 epitope is a fragment of the peptide gp41 (659-671) that contains the complete epitope of one of three known antibodies capable of neutralizing a broad spectrum of primary HIV-1 isolates, and is the only such contiguous epitope.
3-苯蒽丁酸 V2383 3-Phenanthrenebutyric acid 13728-56-8 HIV-1 Nef-IN-1 is an inhibitor (blocker/antagonist) of HIV-1 Nef protein that effectively competes for the Nef-SH3Hck interaction with Kd of 6.7 μM.
4-Deoxy-4α-phorbol V76170 4-Deoxy-4α-phorbol 37415-57-9 4-Deoxy-4α-phorbol is a tetracyclic diterpenoid found in E.
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