The epidermal growth factor receptor (EGFR; ErbB1) is a member of the epidermal growth factor RTK (receptor tyrosine kinases) family, along with HER2/neu (ErbB2), ErbB3 (HER3), and ErbB4 (HER4). The extracellular ligand-binding ectodomain, the single chain transmembrane domain, and the intracellular tyrosine kinase domain make up the EGFR, which is located at the cell surface. Epidermal growth factor (EGF), transforming growth factor (TGF-α), amphiregulin, heparin-binding EGF, and betacellulin are just a few of the ligands that bind to and activate the EGFR.
The tyrosine kinase domain is activated by the receptors' formation of homo- or heterodimeric complexes after ligand binding. The Ras-Raf-MAP kinase, PI-3K/Akt, PKC, and Stat/Jak signaling pathways are all activated as a result of the dimerization and autophosphorylation of EGFR. The EGFR is activated to control cellular survival, differentiation, and proliferation. The EGFR has been derided as a proto-oncogene primarily because of its function in encouraging cell proliferation and preventing apoptosis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51518 | (E/Z)-AG490 | 134036-52-5 | (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is the racemate of (E)-AG490 and (Z)-AG490. |
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V87036 | (Rac)-JBJ-04-125-02 acetate | (Rac)-JBJ-04-125-02 acetate is the racemate of JBJ-04-125-02, a potent, mutant-selective, allosteric and orally active EGFR inhibitor. | |
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V88019 | (Z)-RG-13022 | 149286-90-8 | (Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits EGFR TK activity and inhibits EGF-stimulated cultured cell growth. |
![1-Methyl-1H-pyrrolo[2,3-b]pyridine](http://www.invivochem.com/upload/1124/V123606.png)
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V123606 | 1-Methyl-1H-pyrrolo[2,3-b]pyridine | 27257-15-4 | 1-Methyl-1H-pyrrolo[2,3-b]pyridine is a 7-azaindole derivative that can bind to the EGFR kinase domain. |
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V92474 | 13(S)-HPODE | 33964-75-9 | 13(S)-HPODE is a linoleic acid metabolite found in some plants and mammals. |
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V102893 | 4-Epidoxycycline | 6543-77-7 | 4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and has no antibiotic activity in mice. |
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V101861 | 4-Methyl erlotinib | 1346601-52-2 | 4-Methylerlotinib is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. |
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V97045 | 4-Methyl erlotinib (Standard) | 1346601-52-2 | 4-Methyl Erlotinib (Standard) is the analytical standard for 4-methyl Erlotinib. |
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V114168 | AfaPhos1 | AfaPhos1 is a novel EGFR phosphorylation-targeting drug based on afatinib. | |
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V128379 | AFM24 | AFM24 is a bispecific antibody with a TandAb structure, expressed in CHO cells, and targets EGFR and Fcγ-RIIIA. | |
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V128652 | AM9928 | 1869033-49-7 | AM9928 is a monoacylglycerol lipase (MAGL) inhibitor with IC50 and Ki values of 8.9 nM and 7.3 nM, respectively. |
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V128753 | Amivantamab (FUT8-KO) | Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. | |
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V128813 | Andamertinib | 2254145-43-0 | Andamertinib is an EGFR inhibitor with anti-tumor activity. |
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V129015 | Anti-ERBB3/HER3 (29Z6) | Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor that targets human ERBB3/HER3. | |
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V129016 | Anti-ERBB3/HER3 (SGP1) | Anti-ERBB3/HER3 (SGP1) is a human monoclonal antibody (mAb) that targets ERBB3/HER3. | |
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V106376 | Anti-Human/Rat HER2 (neu) Antibody (7.16.4) | Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is a mouse-derived IgG2a, κ antibody inhibitor directed against human or rat HER2. | |
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V129130 | anti-NSCLC agent-1 | anti-NSCLC agent-1 is a tyrosine kinase inhibitor (TKI) with IC50 values of 0.05 and 0.09 μM in A549 and NCI-H441 cells, respectively. | |
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V100619 | Antiproliferative agent-54 | 1240322-54-6 | Antiproliferative agent-54 (compound 6z) is an inhibitor of multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A, and SRC, with IC50 of 6-50 nM. |
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V129189 | Antitumor agent-213 | Antitumor agent-213 is an antitumor drug. | |
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V129204 | Anvatabart | 2636710-06-8 | Anvatabart is an anti-ERBB2 human IgG1κ monoclonal antibody. |
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