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BTK

BTK

Btk, a member of the Tec family of kinases, is well-known for its function in B-cell activation and B-cell antigen receptor (BCR) signaling.

Btk is a new target for diseases with abnormal B cell activity because it is essential for B cell development and activation through the BCR signaling pathway. The human primary immune deficiency disease X-linked agammaglobulinemia (XLA), which is caused by a mutation in the Btk gene, highlights the importance of Btk, a kinase that is only expressed in B cells and myeloid cells.The BCR signaling pathway depends on Btk in many ways. B cell receptor oligomerization, Syk and Lyn kinase activation, and Btk kinase activation are all caused by antigen binding to the BCR. When Btk is activated, it joins forces with proteins like BLNK, Lyn, and Syk to form a signaling complex that phosphorylates phospholipase C (PLC)2. This results in transcriptional changes that promote B cell survival, proliferation, and/or differentiation by releasing intracellular Ca2+ stores downstream and propagating the BCR signaling pathway through extracellular signal-regulated kinase and NF-B signaling.

BTK related products

Structure Cat No. Product Name CAS No. Product Description
(E/Z)-Rilzabrutinib V121811 (E/Z)-Rilzabrutinib 1575591-66-0 (E/Z)-Rilzabrutinib is the cis-trans isomer of Rilzabrutinib.
(R)-Acalabrutinib V87996 (R)-Acalabrutinib 1952316-43-6 (R)-Acalabrutinib ((R)-ACP-196) is an isomer of Acalabrutinib.
(R)-NX-2127 V87995 (R)-NX-2127 3024312-52-2 (R)-NX-2127 (compound 28) is an orally active Bruton's tyrosine kinase (Btk) degrader.
(R,R)-Bexobrutideg V115563 (R,R)-Bexobrutideg 2649400-33-7 (R,R)-Bexobrutideg is the (R,R)-enantiomer of bexobrutideg.
(R,R)-Birelentinib V109231 (R,R)-Birelentinib 2662512-14-1 (R,R)-Birelentinib ((R,R)-DZD8586) (compound 14) is a potent BTK inhibitor with IC50 values of 0.7 nM for wild-type BTK and 0.86 nM for BTK C481S mutant.
(Rac)-Ibrutinib alkyne V119798 (Rac)-Ibrutinib alkyne 936563-91-6 (Rac)-ibrutinib alkyne (compound 8) is a Btk inhibitor with an IC50 of 0.72 nM.
(Z)-LFM-A13 V0647 (Z)-LFM-A13 244240-24-2 (Z)-LFM-A13 (LFM-A1-3) is a novel, potent and specific Brutons tyrosine kinase (BTK) inhibitor with potential anticancer activity.
2-(Bromomethyl)acrylic acid V123855 2-(Bromomethyl)acrylic acid 72707-66-5 2-(Bromomethyl)acrylic acid is a Bruton's tyrosine kinase (BTK) inhibitor.
ABBV-992 V89055 ABBV-992 2792171-84-5 ABBV-992 is a potent and selective BTK inhibitor.
Acalabrutinib maleate V108927 Acalabrutinib maleate 2242394-65-4 Acalatinib maleate is an orally effective, irreversible, and highly selective second-generation BTK inhibitor.
AMX5160 V128793 AMX5160 2639293-95-9 AMX5160 is an orally effective BTK inhibitor with an IC50 of 0.98 nM against mutant BTKC481S.
BIIB129 V87994 BIIB129 2770960-52-4 BIIB129 is a covalent, selective, blood-brain barrier-penetrating small molecule inhibitor of Bruton's tyrosine kinase (BTK).
BTK C481R Recombinant Human Active Protein Kinase V118843 BTK C481R Recombinant Human Active Protein Kinase Bruton's tyrosine kinase (BTK) plays a key role in the B cell antigen receptor (BCR) signaling pathway.
BTK degrader-1 intermediate V130711 BTK degrader-1 intermediate 2377643-84-8 BTK degrader-1 intermediate is an intermediate in the synthesis of BTK degrader-1.
BTK degrader-2 V114529 BTK degrader-2 2649400-05-3 BTK degrading enzyme-2 (Example 2) is a bifunctional BTK degrading enzyme that degrades BTK via the ubiquitin-proteasome pathway.
BTK inhibitor 27 V5248 BTK inhibitor 27 2230724-66-8 BTK inhibitor 27, compound 27 in the cited reference below, is apyrrolo[2,3-d]pyrimidine based BTK inhibitor with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.
BTK ligand 16 V119634 BTK ligand 16 BTK ligand 16 is a BTK ligand that can be used to synthesize TQ-3959.
BTK ligand-17 V130714 BTK ligand-17 BTK ligand-17 is a BTK ligand.
BTK ligand-19 V130715 BTK ligand-19 BTK ligand-19 is a PROTAC ligand for BTK, used to synthesize PROTAC-based BTK degrader PROTAC BTK degrader-14.
BTK ligand-20 V130716 BTK ligand-20 BTK ligand-20 is a BTK ligand.
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