The AGC (PKA/PKG/PKC) family of serine-threonine kinases includes ROCK (Rho-associated protein kinase). Animals such as chicken, zebrafish, Xenopus, and mammals also have ROCKs (ROCK1 and ROCK2). With a molecular weight of 158 kDa, human ROCK1 is a significant RhoA small GTPase downstream effector. A kinase domain, an acoiled-coil region, and a Pleckstrin homology (PH) domain make up a mammalian ROCK. If RhoA-GTP is absent, the kinase activity of ROCKs is reduced by an autoinhibitory intramolecular fold. Since ROCK is a downstream effector protein of the small GTPase Rho, one of the primary regulators of the cytoskeleton, ROCK is involved in a variety of different cellular phenomena.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1346 | RKI-1447 | 1342278-01-6 | RKI-1447 (ROCK Inhibitor XIII; RKI 1447; RKI1447) is a potent small molecule inhibitor of ROCK1 and ROCK2 with potential antitumor activities againstbreast cancer. |
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V55726 | ROCK-IN-5 | 692870-25-0 | ROCK-IN-5 (compound IB-37) is a potent inhibitor of ROCK, ERK, GSK and AGC protein kinases. |
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V55727 | ROCK-IN-6 | 2489328-74-5 | ROCK-IN-6 is a potent ROCK2 inhibitor (antagonist) with IC50 of 2.19 nM. |
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V55725 | ROCK-IN-7 | 2376635-95-7 | ROCK-IN-7 (compound 9) is a ROCK kinase inhibitor. |
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V55724 | ROCK-IN-8 | 1621103-79-4 | ROCK-IN-8 (Example 4) is a ROCK inhibitor (antagonist) with IC50 of less than 100 nM. |
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V55728 | ROCK-IN-9 | 2643334-76-1 | ROCK-IN-9 (Compound T345) is a ROCK inhibitor. |
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V55729 | ROCK2-IN-6 | 2260506-59-8 | ROCK2-IN-6 (Comp A) is a selective ROCK2 inhibitor for the study of ROCK-mediated diseases, autoimmune diseases, and inflammation. |
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V53327 | ROCK2-IN-6 hydrochloride | 2762238-94-6 | ROCK2-IN-6 HCl (Comp A) is a selective ROCK2 inhibitor for research into ROCK-mediated diseases, autoimmune diseases, and inflammation. |
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V2556 | SAR-020106 | 1184843-57-9 | SAR-020106 is a potent,ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nM on isolated human enzyme. |
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V3093 | SAR-407899 | 923359-38-0 | SAR407899 is a novel, potent, selective, and ATP-competitiveROCKinhibitor with anIC50of 135 nM forROCK-2, andKis of 36 nM and 41 nM for human and ratROCK-2, respectively. |
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V35267 | Sovesudil (PHP-201; AMA0076) | 1333400-14-8 | Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor (antagonist) with IC50s of 3.7 and 2.3 nM for ROCK I and ROCK II, respectively. |
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V1343 | Thiazovivin | 1226056-71-8 | Thiazovivin (TZV) is a novel, selective, and cell-permeable small molecule ROCK (Rho-associated kinase) inhibitor with an IC50 of 0.5 μM in a cell-free assay. |
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V35201 | THK01 | 2226941-26-8 | THK01 is a potent ROCK2 inhibitor (antagonist) with IC50s of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. |
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V2557 | THZ1 | 1604810-83-4 | THZ1 (THZ-1) is a novel, potent, selective and covalent/irreversible CDK7 inhibitor (IC50 = 3.2 nM) with anticancer activity. |
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V1184 | Wogonin | 632-85-9 | Wogonin (Vogonin), a naturally occurring and pharmacologically-active flavonoid found in plants, has been reported to exhibit anticancer effects against various cancer cell types such as osteosarcoma, leukemia, breast cancer and glioma. |
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V3416 | Y-27632 | 146986-50-7 | Y-27632 is a potent and selective inhibitor of ROCK1 (p160ROCK) with IC50 of 140 nM in a cell-free assay, it exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
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V1342 | Y-27632 2HCl | 129830-38-2 | Y-27632 2HCl (Y27632;Y2 7632), the dihydrochloride salt ofY-27632,is a novel, potent and selective inhibitor of ROCK1 (p160ROCK) with potential antifibrotic and anticancer activity. |
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V26655 | Y-33075 hydrochloride (Y-39983) | 471843-75-1 | Y-33075 HCl (Y-39983) is a selective ROCK inhibitor, derived from Y-27632, with IC50 of 3.6 nM, which is more effective than Y-27632. |
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V3415 | Y-39983 | 199433-58-4 | Y-39983 (also calledY-33075)is a novel, potent and selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6 nM, 0.42 μM and 0.81 μM for ROCK, PKC and CaMKII, respectively. |
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V2559 | Y-39983 HCl (Y-33075) | 173897-44-4 | Y-39983 HCl (also calledY-33075)is a novel, potent and selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6 nM, 0.42 μM and 0.81 μM for ROCK, PKC and CaMKII, respectively. |
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