YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.
YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V39633 | YAP-TEAD-IN-1 TFA | 1659305-79-9 | YAP-TEAD-IN-1 TFA is a potent competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). |
|
V69182 | YAP-TEAD-IN-2 | 2714432-83-2 | YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor (antagonist) with IC50 of 2.7 nM. |
|
V69177 | YAP-TEAD-IN-3 | 2714434-21-4 | YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. |
|
V73474 | YTP-17 | YTP-17 is an orally bioactive YAP-TEAD protein-protein interaction inhibitor (antagonist) with IC50 of 4 nM. |
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