STAT

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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STAT

The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.

STAT related products

Cat No.	Product Name	CAS No.	Product Description
V87049	STAT6-IN-5	3033742-22-9	STAT6-IN-5 (34) is a STAT6 inhibitor with an IC50 value of 0.24 μM.
V79653	Syk-IN-6	3018859-95-2	Syk-IN-6 is an inhibitor (blocker/antagonist) of lipid-SH2 domain interactions and controls the cellular activity of SH2 domain-containing kinases.
V51536	W-1131	2740522-79-4	W1131 is a potent STAT3 activator that induces ferroptosis (ferroptosis).
V87060	WB518		WB518 is a potent STAT3 inhibitor.
V93751	WZ-2-033	2416196-47-7	WZ-2-033 is a potent STAT3 inhibitor.
V1380	Stattic	19983-44-9	Stattic (6-Nitro-1-benzothiophene 1,1-dioxide) isa small molecule inhibitor of STAT3 that potently inhibits STAT3 activation and nuclear translocation with potential antineoplastic activity.
V1382	Nifuroxazide	965-52-6	Nifuroxazide (Bacifurane; Diafuryl;Ambatrol; Antinal;Diarlidan) is a potent,cell-permeable and orally bioavailable nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
V1386	Napabucasin (BBI-608)	83280-65-3	Napabucasin (formerly also known as BBI-608; BBI608; BBI 608) is a novel, potent, and orally bioavailable cancer cell stemness inhibitor with potential antineoplastic activity.
V1383	Cryptotanshinone (Cryptotanshinon)	35825-57-1	Cryptotanshinone (also called Cryptotanshinon; Tanshinone c), a naturally occuring compound found from the roots of Salvia miltiorrhiza Bunge (Danshen, a Chinesemedicinal plant), is a potent STAT3 inhibitor with potential antitumor activity.