The -phosphate group of ATP is transferred to protein substrates by the Ser/Thr phosphoryl transferase known as PKA. More than 100 membrane- and cytoplasmic-associated targets are phosphorylated by PKA. PKA mediates a wide range of cellular signaling activities, and its activity is strictly controlled in both time and space.
The hedgehog (Hh) signal transduction pathway is negatively regulated by PKA, an evolutionary conserved protein. The proteolytic processing step that results in the repressor forms of the Ci and Gli transcription factors, which turn off target genes in the absence of Hh, is known to require PKA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V76625 | PKI 14-22 amide,myristoylated TFA | PKI 14-22 amide,myristoylated TFA is a potent inhibitor of cAMP-dependent PKA. | |
|
V69114 | PKI(14-24)amide | 100853-61-0 | PKI (14-24)amide is a potent PKA inhibitor. |
|
V81159 | PKI(5-24) TFA | PKI(5-24) TFA is a potent, competitive, synthetic inhibitor of PKA (cAMP-dependent protein kinase) with a Ki of 2.3 nM. | |
|
V69122 | Rp-8-CPT-cAMPS | 129735-01-9 | Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced cAMP-dependent activation of PKA I and PKA II. |
|
V69115 | Rp-8-CPT-cAMPS sodium | 221905-35-7 | Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced cAMP-dependent activation of PKA I and PKA II. |
|
V69125 | Rp-cAMPS | 73208-40-9 | Rp-cAMPS, a cAMP analog, is a potent, competitive antagonist of cAMP-induced activation of PKA I and PKA II (Ki 12.5 µM and 4.5 µM, respectively). |
|
V69107 | Rp-cAMPS sodium salt | 142439-94-9 | Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive antagonist of cAMP-induced PKA I and PKA II activation (Ki 12.5 µM and 4.5 µM, respectively). |
|
V69117 | Sp-5,6-DCl-cBIMPS | 120912-54-1 | Sp-5,6-DCl-cBIMPS is a potent and specific activator of cAMP-dependent protein kinase (cAMP-PK). |
|
V69123 | Sp-8-CPT-cAMPS | 129693-13-6 | Sp-8-CPT-cAMPS, a cAMP analog, is a potent and specific activator of cAMP-dependent protein kinase A PKA I and PKA II. |
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