The ubiquitous Ser/Thr kinases known as casein kinases (CKs) control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the ubiquitin-proteasome system (UPS). Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) have both been extensively characterized.
Mammals have at least seven different isoforms of CK1 kinases (,, 1-3,, and ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis.A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V35259 | SR-1277 | 1446715-47-4 | SR-1277 is a specific and ATP-competitive CK1δ/ε inhibitor (antagonist) with IC50s of 49 nM and 260 nM, respectively. |
|
V78620 | SR-4133 | SR-4133 is a potent and specific inhibitor of CK1ε with IC50 of 58 nM. | |
|
V15644 | TA-01 | 1784751-18-3 | TA-01 is a potent inducer of cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. |
|
V35188 | TMX-4113 | 2766385-92-4 | TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). |
|
V35187 | TMX-4116 | 2766385-56-0 | TMX-4116 is a casein kinase 1α (CK1α) degrader. |
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