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Fungal

Fungal

A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.

Fungal related products

Structure Cat No. Product Name CAS No. Product Description
(+)-β-Pinene V121209 (+)-β-Pinene 19902-08-0 (+)-β-Pinene is an enantiomer of (-)-β-pinene.
(-)-Mitorubrinic acid V117708 (-)-Mitorubrinic acid 58958-07-9 (-)-Mitorublinic acid is a polyketide compound.
(-)-Oxysporidinone V121153 (-)-Oxysporidinone 884604-98-2 (-)-Oxysporidinone is an antifungal drug.
(-)-Zonarol V121160 (-)-Zonarol 110715-67-8 (-)-Zonarol is an antifungal agent.
(10E,12E)-9-Oxo-10,12-octadecadienoic acid V88758 (10E,12E)-9-Oxo-10,12-octadecadienoic acid 54232-58-5 (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist isolated from the basidiomycete Gomphus floccosus.
(25RS)-Schidegera saponin D1 V109736 (25RS)-Schidegera saponin D1 266997-53-9 (25RS)-Yucca saponin D1 is an anti-yeast steroidal saponin that has significant inhibitory activity against food spoilage yeasts and film-forming yeasts.
(25RS)-Schidigera-saponin E1 V109543 (25RS)-Schidigera-saponin E1 266998-23-6 (25RS)-Yucca saponin E1 is a steroidal saponin with anti-yeast activity, isolated from the stem of yucca (Mojave yucca).
(2S)-Hydroxy Itraconazole-d8 V121455 (2S)-Hydroxy Itraconazole-d8 (2S)-Hydroxy Itraconazole-d8 is the enantiomer of hydroxyitraconazole-d8 (R-63373-d8).
(3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid V121579 (3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid 112667-17-1 (3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid is an oleanane-type triterpenoid saponin.
(4S)-(+)-Ascochin V91048 (4S)-(+)-Ascochin 935699-58-4 (4S)-(+)-Ascochin is an antifungal agent that inhibits Microbotryum violaceum, Phytophthora infestans and Septoria tritici.
(E)-4-Methyl-5-styrylbenzene-1,3-diol V90886 (E)-4-Methyl-5-styrylbenzene-1,3-diol 2407559-34-4 (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent extracted from Dracaena cochinchinensis (Lour.) SC Chen.
(E/Z)-Tapinarof V121814 (E/Z)-Tapinarof 115781-08-3 (E/Z)-Tapinarof is a broad-spectrum antibiotic.
(Gly0.8Nap0.2)20 V103811 (Gly0.8Nap0.2)20 (Gly0.8Nap0.2)20 is a dual-targeting compound against fungal membranes and DNA.
(Rac)-Epoxiconazole V122015 (Rac)-Epoxiconazole 135319-73-2 (Rac)-Epoxiconazole is a chiral triazole fungicide that is released into the environment in racemic form and has broad-spectrum, long-lasting and excellent fungicidal effects.
(RS)-Sakuranetin V102712 (RS)-Sakuranetin 520-29-6 (RS)-Sakuranetin is the racemate of Sakuranetin.
(S)-Hydroxy Itraconazole-d8 V116737 (S)-Hydroxy Itraconazole-d8 (S)-hydroxyitraconazole-d8 ((S)-R-63373-d8) is the enantiomer of hydroxyitraconazole-d8 (R-63373-d8).
(±)-Coladonin V114956 (±)-Coladonin 57525-77-6 (±)-Coradonine (compound (±)-12) is a coumarin derivative with antifungal activity.
(±)-Dunnione V102647 (±)-Dunnione 521-49-3 (±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling.
(±)-Lomatin V121240 (±)-Lomatin 1147-25-7 (±)-Lomatin is a coumarin secondary metabolite.
(−)-Voacangarine V121159 (−)-Voacangarine 545-84-6 (−)-Voacangarine is an indole alkaloid that exhibits cytotoxic effects on cancer cells such as HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26, with an IC50 value of 5–20 mg/mL.
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