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Fungal

Fungal

A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.

Fungal related products

Structure Cat No. Product Name CAS No. Product Description
(-)-Mitorubrinic acid V117708 (-)-Mitorubrinic acid 58958-07-9 (-)-Mitorublinic acid is a polyketide compound.
(10E,12E)-9-Oxo-10,12-octadecadienoic acid V88758 (10E,12E)-9-Oxo-10,12-octadecadienoic acid 54232-58-5 (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist isolated from the basidiomycete Gomphus floccosus.
(25RS)-Schidegera saponin D1 V109736 (25RS)-Schidegera saponin D1 266997-53-9 (25RS)-Yucca saponin D1 is an anti-yeast steroidal saponin that has significant inhibitory activity against food spoilage yeasts and film-forming yeasts.
(25RS)-Schidigera-saponin E1 V109543 (25RS)-Schidigera-saponin E1 266998-23-6 (25RS)-Yucca saponin E1 is a steroidal saponin with anti-yeast activity, isolated from the stem of yucca (Mojave yucca).
(4S)-(+)-Ascochin V91048 (4S)-(+)-Ascochin 935699-58-4 (4S)-(+)-Ascochin is an antifungal agent that inhibits Microbotryum violaceum, Phytophthora infestans and Septoria tritici.
(E)-4-Methyl-5-styrylbenzene-1,3-diol V90886 (E)-4-Methyl-5-styrylbenzene-1,3-diol 2407559-34-4 (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent extracted from Dracaena cochinchinensis (Lour.) SC Chen.
(Gly0.8Nap0.2)20 V103811 (Gly0.8Nap0.2)20 (Gly0.8Nap0.2)20 is a dual-targeting compound against fungal membranes and DNA.
(RS)-Sakuranetin V102712 (RS)-Sakuranetin 520-29-6 (RS)-Sakuranetin is the racemate of Sakuranetin.
(S)-Hydroxy Itraconazole-d8 V116737 (S)-Hydroxy Itraconazole-d8 (S)-hydroxyitraconazole-d8 ((S)-R-63373-d8) is the enantiomer of hydroxyitraconazole-d8 (R-63373-d8).
(±)-Coladonin V114956 (±)-Coladonin 57525-77-6 (±)-Coradonine (compound (±)-12) is a coumarin derivative with antifungal activity.
(±)-Dunnione V102647 (±)-Dunnione 521-49-3 (±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling.
1-Heptadecene V115117 1-Heptadecene 6765-39-5 1-Heptadecane is a metabolite found in the heartwood tree (Aporosa cardiosperma).
10-Undecenoic acid (copper) V105650 10-Undecenoic acid (copper) 35322-29-3 Copper 10-undecenoate (undecylenate) was used as the starting reagent for the synthesis of the pheromone (11Z)-hexadecenal.
13-Hydroxy-9-octadecenoic acid V97796 13-Hydroxy-9-octadecenoic acid 324575-43-1 13-Hydroxy-9-octadecenoic acid is a hydroxyunsaturated fatty acid (HUFA) with antifungal activity.
14α-Demethylase-IN-1 V94976 14α-Demethylase-IN-1 3026164-55-3 14α-Demethylase-IN-1 (Compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent.
1β-Acetoxypolygodial V118291 1β-Acetoxypolygodial 1818425-44-3 1β-acetoxypolysaccharide is a sesquiterpene compound found in Tasmania lanceolata.
2′-Hydroxychalcone V89726 2′-Hydroxychalcone 1214-47-7 2'-Hydroxychalcone is a hydroxy derivative of chalcone with anticancer activity.
2,3,5-Tri-O-benzyl-D-ribose V106715 2,3,5-Tri-O-benzyl-D-ribose 54623-25-5 2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is a potent inhibitor of chitin synthase (CHS) from Botrytis cinerea with IC50 of 1.8 μM.
2,3-Dichloro-1,4-naphthoquinone V105685 2,3-Dichloro-1,4-naphthoquinone 117-80-6 2,3-Dichloro-1,4-naphthoquinone is an effective fungicide.
2,5-Dimethylhexane-3,4-diol V115454 2,5-Dimethylhexane-3,4-diol 22607-11-0 2,5-Dimethylhexane-3,4-diol is an active ingredient extracted from *Phimbe mansonia*.
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