A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V106518 | Lactose octaacetate | 6291-42-5 | Lactose octaacetate has mild to moderate antifungal activity against some fungi but has low or no activity against bacteria and yeasts. |
|
V91773 | Malolactomycin C | 189759-03-3 | Malolactomycin C (compound 1) is a macrolide antifungal antibiotic isolated from Streptomyces strain KP-3144. |
|
V91015 | Neodidymelliosides A | Neodidymelliosides A (compound 1) is a fungal secondary metabolite with significant inhibitory effects on Staphylococcus aureus and Candida albicans biofilms. | |
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V91748 | Neosartoricin B | 1421708-43-1 | Neosartoricin B is a secondary metabolite produced by Aspergillus nidulans. |
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V50942 | Nifuroxime (CCRIS-1180) | 6236-05-1 | Nifuroxime is an anti-infection agent utilized in the research related to fungal infections. |
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V94349 | Nitrofungin | 619-08-9 | Nitrofungin (2-chloro-4-nitrophenol) is an antifungal agent that can be degraded by some bacteria. |
|
V87287 | NP-BTA | 544420-99-7 | NP-BTA is an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS). |
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V88183 | Oligomycin E | 110231-34-0 | Oligomycin E is an antitumor antibiotic that can be isolated from Streptomyces. |
|
V90917 | Oryzalexin E | 150943-96-7 | Oryzalexin E is a diterpene phytoalexin that can be isolated from UV-irradiated rice leaves. |
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V97014 | p-Terphenyl (Standard) | 92-94-4 | p-Terphenyl (Standard) is the analytical standard for p-Terphenyl. |
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V101667 | Perinaphthenone | 548-39-0 | The naphthothone exhibited antifungal activity with IC50 values of 36.2 μM (day 3), 13.3 μM (day 3), and 39.0 μM (60 h) against Botrytis cinerea, Fusarium spp., and Botrytis cinerea, respectively. |
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V102810 | PF-1163A | 258871-59-9 | PF-1163A is an antifungal agent that inhibits ergosterol synthesis in Penicillium fermentation broth (IC50 = 12 ng/mL). |
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V103924 | Poacic acid | 160097-32-5 | Valeric acid is a plant-derived stilbene compound with antifungal activity. |
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V88340 | Polycarpine hydrochloride | 175669-29-1 | Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50= 30 nM) isolated from Polycarpa aurata and is also an anti-coronavirus agent. |
|
V104832 | Pradimicin L | 142062-87-1 | Pradimicin L is a homologue of pradimicin A, which can be isolated from the actinomycete Trichoderma madura subsp. neomycin and has antifungal activity. |
|
V91756 | Prolylrapamycin | 156223-31-3 | Prolylrapamycin (21-Norrapamycin) is a derivative of rapamycin. |
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V93182 | Pyraoxystrobin | 862588-11-2 | Pyraclostrobin is a QoI fungicide with an EC50 of 0.0094 μg/mL against isolates of the rice blast pathogen. |
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V88181 | Quindecamine acetate | 19146-62-4 | Quindecamine acetate is a derivative of Quinaldine. |
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V91113 | Radulone A | 221374-79-4 | Radulone A is a secondary metabolite isolated from the wood decomposing fungus Granulobasidium vellereum. |
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V102860 | Roridin E | 16891-85-3 | Roridin E is an antibiotic with cytostatic and bacteriostatic activities similar to those of Verrucarin. |
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