A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V93912 | Antifungal agent 121 | 343362-45-8 | Antifungal agent 121 (compound TM11) is a fungicide. |
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V105002 | Antifungal agent 124 | Antifungal agent 257 (compound 7e) is a broad-spectrum antifungal agent with an EC50 value of 4.15 μM against Fusarium graminearum. | |
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V90771 | Antifungal agent 91 | Antifungal agent 91 (compound 1) is a dihydroflavonol isolated from the leaves of Artocarpus elasticus. | |
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V103900 | Antifungal agent 92 | 3020687-94-6 | Antifungal agent 92 (compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. |
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V103523 | Antifungal agent 94 | 3030502-21-4 | Antifungal agent 94 (compound 49) is a flavonoid derivative that exhibits antifungal activity against Rhizoctonia solani with an EC50 of 0.28 μM and a half-maximal effective concentration of 0.46 μg/mL. |
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V103524 | Antifungal agent 95 | 2883716-51-4 | Antifungal agent 95 (compound CN21b) is an antifungal agent against Sclerotinia sclerotiorum and Botrytis cinerea with EC50 values of 2.11 and 0.97 μM, respectively. |
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V103795 | Antifungal agent 96 | Antifungal agent 96 (compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. The growth inhibition MICs of antifungal agent 96 against Cryptococcus neoformans H99 and Candida albicans 0304103 were 0.016 and 32 μg/mL, respectively. | |
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V102412 | Antifungal agent 98 | 4771-50-0 | Antifungal 98 (Compound 2) is an antifungal agent. |
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V103887 | Antifungal agent 99 | Antifungal 99 is a fungal succinate dehydrogenase (SDH) inhibitor. | |
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V105935 | Antimycin A2 | 27220-57-1 | Antimycin A2 is a component of Antimycin A. |
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V11513 | APX001A (Manogepix; E 1210) | 936339-60-5 | APX001A (Manogepix, E1210) is a first-in-class,broad-spectrum and orally bioactive inhibitor of the fungal protein Gwt1 (GPI-anchored wall transfer protein 1) in the glycosylphosphatidylinositol (GPI) biosynthesis pathway. |
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V97451 | APX879 | 1801372-27-9 | APX879 is a fungus-specific calcineurin inhibitor with reduced immunosuppressive activity and toxicity. |
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V91012 | AS-2077715 | 1637356-98-9 | AS-2077715 is an antifungal agent that exhibits inhibitory activity against Trichophyton spp. |
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V105996 | Aselacin C | 156223-08-4 | Aselacin C is a cyclic peptide isolated from the fungus Acremonium spp. |
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V101992 | Aspyrone | 17398-00-4 | Aspyrone is a polyketide fungal metabolite present in Aspergillus species with multiple biological activities. |
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V94949 | Benodanil | 15310-01-7 | Benzanilide (NSC 100499) is a benzanilide fungicide widely used in agriculture. |
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V91775 | Burnettramic acid A | 2334483-46-2 | Burnettramic acid A is an antibiotic isolated from Aspergillus burnettii. |
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V91050 | Chaetoviridin A | 128252-98-2 | Chaetoviridin A exhibits antifungal activity against a variety of plant pathogens and inhibits the growth of Verticillium dahliae through cell necrosis and hyphal deformation, thereby increasing the sensitivity of Verticillium dahliae to stress and improving the emergence rate and plant height of cotton. |
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V92149 | Cinnamon bark oil, from Cinnamonum zeylanicum Blume | 8015-91-6 | Cinnamon bark oil, from Cinnamonum zeylanicum Blume, is a mycotoxicant that has toxic effects on fungi that cause respiratory mycoses. |
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V91034 | Concanamycin C | 81552-34-3 | Concanamycin C inhibits the proliferation of mouse spleen lymphocytes. |
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